期刊论文详细信息
Parasite
Clinical and translational research in Pneumocystis and Pneumocystis pneumonia
L. Huang1 
[1] Division of Pulmonary and Critical Care Medicine and HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco,USA
关键词: acquired immune deficiency syndrome (AIDS);    human immunodeficiency virus (HIV);    Pneumocystis pneumonia (PcP);    colonization;    Pneumocystis;   
Others  :  808878
DOI  :  doi:10.1051/parasite/2011181003
 received in 2010-08-24, accepted in 2010-10-11,  发布年份 2011
PDF
【 摘 要 】

Pneumocystis pneumonia (PcP) remains a significant cause of morbidity and mortality in immunocompromised persons, especially those with human immunodeficiency virus (HIV) infection. Pneumocystis colonization is described increasingly in a wide range of immunocompromised and immunocompetent populations and associations between Pneumocystis colonization and significant pulmonary diseases such as chronic obstructive pulmonary disease (COPD) have emerged. This mini-review summarizes recent advances in our clinical understanding of Pneumocystis and PcP, describes ongoing areas of clinical and translational research, and offers recommendations for future clinical research from researchers participating in the “First centenary of the Pneumocystis discovery”.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2011

【 预 览 】
附件列表
Files Size Format View
20140708180041691.pdf 162KB PDF download
Fig. 1. 48KB Image download
【 图 表 】

Fig. 1.

【 参考文献 】
  • [1]Alvarez-Martinez M.J., Moreno A., Miro J.M., Valls M.E., Rivas P.V., de Lazzari E., Sued O., Benito N., Domingo P., Ribera E., Santin M., Sirera G., Segura F., Vidal F., Rodriguez F., Riera M., Cordero M.E., Arribas J.R., Jimenez de Anta M.T., Gatell J.M., Wilson P.E. & Meshnick S.R. Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality. Diagn Microbiol Infect Dis, 2008, 62, 34–43. [PubMed]
  • [2]Azoulay E., Bergeron A., Chevret S., Bele N., Schlemmer B. & Menotti J. Polymerase chain reaction for diagnosing Pneumocystis pneumonia in non-HIV immunocompromised patients with pulmonary infiltrates. Chest, 2009, 135, 655–661. [PubMed]
  • [3]Beard C.B., Carter J.L., Keely S.P., Huang L., Pieniazek N.J., Moura I.N., Roberts J.M., Hightower A.W., Bens M.S., Freeman A.R., Lee S., Stringer J.R., Duchin J.S., del Rio C., Rimland D., Baughman R.P., Levy D.A., Dietz V.J., Simon P. & Navin T.R. Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission. Emerg Infect Dis, 2000, 6, 265–272. [PubMed]
  • [4]Beard C.B., Fox M.R., Lawrence G.G., Guarner J., Hanzlick R.L., Huang L., del Rio C., Rimland D., Duchin J.S. & Colley D.G. Genetic differences in Pneumocystis isolates recovered from immunocompetent infants and from adults with AIDS: epidemiological implications. J Infect Dis, 2005, 192, 1815–1818. [PubMed]
  • [5]Benfield T., Atzori C., Miller R.F. & Helweg-Larsen J. Second line salvage treatment of AIDS-associated Pneumocystis jirovecii pneumonia: a case series and systematic review. J Acquir Immune Defic Syndr, 2008, 48, 63–67. [PubMed]
  • [6]Calderon E.J., Rivero L., Respaldiza N., Morilla R., Montes-Cano M.A., Friaza V., Munoz-Lobato F., Varela J.M., Medrano F.J. & de la Horra C. Systemic inflammation in patients with chronic obstructive pulmonary disease who are colonized with Pneumocystis jiroveci. Clin Infect Dis, 2007, 45, e17–19. [PubMed]
  • [7]Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report. 1990.
  • [8]Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report. 1991.
  • [9]Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report. 1992.
  • [10]Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report. 1993.
  • [11]Crothers K., Beard C.B., Turner J., Groner G., Fox M., Morris A., Eiser S. & Huang L. Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations. AIDS, 2005, 19, 801–805. [PubMed]
  • [12]Davis J.L. & Huang L. Pneumocystis pneumonia, in: Global HIV/AIDS medicine. Volberding P.A., Sande M.A., Lange J. & Greene W.C. (eds), First ed., Saunders Elsevier, Inc., Philadelphia, 2007, 309–321.
  • [13]Davis J.L., Welsh D.A., Beard C.B., Jones J.L., Lawrence G.G., Fox M.R., Crothers K., Morris A., Charbonnet D., Swartzman A.; & Huang L. Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia. Thorax, 2008, 63, 329–334. [PubMed]
  • [14]de Oliveira A., Unnasch T.R., Crothers K., Eiser S., Zucchi P., Moir J., Beard C.B., Lawrence G.G. & Huang L. Performance of a molecular viability assay for the diagnosis of Pneumocystis pneumonia in HIV-infected patients. Diagn Microbiol Infect Dis, 2007, 57, 169–176. [PubMed]
  • [15]Desmet S., van Wijngaerden E., Maertens J., Verhaegen J., Verbeken E., de Munter P., Meersseman W., van Meensel B., van Eldere J. & Lagrou K. Serum (1–3)-beta-D-glucan as a tool for diagnosis of Pneumocystis jirovecii pneumoniain patients with human immunodeficiency virus infection or hematological malignancy. J Clin Microbiol, 2009, 47, 3871–3874. [PubMed]
  • [16]Esteves F., Montes-Cano M.A., de la Horra C., Costa M.C., Calderon E.J., Antunes F. & Matos O. Pneumocystis jirovecii multilocus genotyping profiles in patients from Portugal and Spain. Clin Microbiol Infect, 2008, 14, 356–362. [PubMed]
  • [17]Fei M.W., Sant C.A., Kim E.J., Swartzman A., Davis J.L., Jarlsberg L.G. & Huang L. Severity and outcomes of Pneumocystis pneumonia in patients newly diagnosed with HIV-infection: an observational cohort study. Scand J Infect Dis, 2009a, 41, 672–678.
  • [18]Fei M.W., Kim E.J., Sant C.A., Jarlsberg L.G., Davis J.L., Swartzman A. & Huang L. Predicting mortality from HIV-associated Pneumocystis pneumonia at illness presentation: an observational cohort study. Thorax, 2009b, 64, 1070–1076.
  • [19]Fisk D.T., Meshnick S. & Kazanjian P.H. Pneumocystis carinii pneumonia in patients in the developing world who have acquired immunodeficiency syndrome. Clin Infect Dis, 2003, 36, 70–78. [PubMed]
  • [20]Fisk M., Sage E.K., Edwards S.G., Cartledge J.D. & Miller R.F. Outcome from treatment of Pneumocystis jirovecii pneumonia with co-trimoxazole. Int J STD AIDS, 2009, 20, 652–653. [PubMed]
  • [21]Helweg-Larsen J., Benfield T., Atzori C. & Miller R.F. Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tricentre cohort study. J Antimicrob Chemother, 2009, 64, 1282–1290. [PubMed]
  • [22]Helweg-Larsen J., Benfield T.L., Eugen-Olsen J., Lundgren J.D. & Lundgren B. Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia. Lancet, 1999, 354, 1347–1351. [PubMed]
  • [23]Huang L., Hecht F.M., Stansell J.D., Montanti R., Hadley W.K. & Hopewell P.C. Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful? Am J Respir Crit Care Med, 1995, 151, 1866–1871. [PubMed]
  • [24]Huang L., Beard C.B., Creasman J., Levy D., Duchin J.S., Lee S., Pieniazek N., Carter J.L., del Rio C., Rimland D. & Navin T.R. Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene. J Infect Dis, 2000, 182, 1192–1198. [PubMed]
  • [25]Huang L., Crothers K., Atzori C., Benfield T., Miller R., Rabodonirina M. & Helweg-Larsen J. Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance. Emerg Infect Dis, 2004, 10, 1721–1728. [PubMed]
  • [26]Huang L., Quartin A., Jones D. & Havlir D.V. Intensive care of patients with HIV infection. N Engl J Med, 2006, 355, 173–181. [PubMed]
  • [27]Jagannathan P., Davis E., Jacobson M. & Huang L. Life-threatening immune reconstitution inflammatory syndrome after Pneumocystis pneumonia: a cautionary case series. AIDS, 2009, 23, 1794–1796. [PubMed]
  • [28]Kazanjian P., Armstrong W., Hossler P.A., Burman W., Richardson J., Lee C.H., Crane L., Katz J. & Meshnick S.R. Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients. J Infect Dis, 2000, 182, 551–557. [PubMed]
  • [29]Kling H.M., Shipley T.W., Patil S., Morris A. & Norris K.A. Pneumocystis colonization in immunocompetent and simian immunodeficiency virus-infected cynomolgus macaques. J Infect Dis, 2009, 199, 89–96. [PubMed]
  • [30]Larsen H.H., Huang L., Kovacs J.A., Crothers K., Silcott V.A., Morris A., Turner J.R., Beard C.B., Masur H. & Fischer S.H. A prospective, blinded study of quantitative touch-down polymerase chain reaction using oral-wash samples for diagnosis of Pneumocystis pneumonia in HIV-infected patients. J Infect Dis, 2004, 189, 1679–1683. [PubMed]
  • [31]Limper A.H., Offord K.P., Smith T.F. & Martin W.J. 2ND. Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS. Am Rev Respir Dis, 1989, 140, 1204–1209. [PubMed]
  • [32]Magne D., Lacube P., Angoulvant A., Meliani L., Botterel F., Bougnoux M.E., Chochillon C., Cornet M., Dannaoui E., Datry A., Dunand J., Galeazzi G., Bouges-Michel C., Yera H., Sarfati C. & Roux P. Pneumocystosis: survey and DHPS genotype analysis in 14 Parisian hospitals in 2003 and 2004. J Eukaryot Microbiol, 2006, 53 (Suppl 1), S106–S107. [PubMed]
  • [33]Miller R.F., Allen E., Copas A., Singer M. & Edwards S.G. Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy. Thorax, 2006, 61, 716–721. [PubMed]
  • [34]Mocroft A., Sterne J.A., Egger M., May M., Grabar S., Furrer H., Sabin C., Fatkenheuer G., Justice A., Reiss P., D’Arminio Monforte A., Gill J., Hogg R., Bonnet F., Kitahata M., Staszewski S., Casabona J., Harris R. & Saag M. Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy: not all AIDS defining conditions are created equal. Clin Infect Dis, 2009, 48, 1138–1151. [PubMed]
  • [35]Morris A., Wachter R.M., Luce J., Turner J. & Huang L. Improved survival with highly active antiretroviral therapy in HIV-infected patients with severe Pneumocystis carinii pneumonia. AIDS, 2003, 17, 73–80. [PubMed]
  • [36]Morris A., Sciurba F.C., Lebedeva I.P., Githaiga A., Elliott W.M., Hogg J.C., Huang L. & Norris K.A. Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization. Am J Respir Crit Care Med, 2004, 170, 408–413. [PubMed]
  • [37]Morris A., Wei K., Afshar K. & Huang L. Epidemiology and clinical significance of Pneumocystis colonization. J Infect Dis, 2008, 197, 10–17. [PubMed]
  • [38]Morris A., Alexander T., Radhi S., Lucht L., Sciurba F.C., Steele C. & Norris K.A. Airway obstruction is increased in Pneumocystis-colonized HIV-infected outpatients. J Clin Microbiol, 2009, 47, 3773–3776. [PubMed]
  • [39]Nakamura H., Tateyama M., Tasato D., Haranaga S., Yara S., Higa F., Ohtsuki Y. & Fujita J. Clinical utility of serumbeta-D-glucan and KL-6 levels in Pneumocystis jirovecii pneumonia. Intern Med, 2009, 48, 195–202. [PubMed]
  • [40]Navin T.R., Beard C.B., Huang L., del Rio C., Lee S., Pieniazek N.J., Carter J.L., Le T., Hightower A. & Rimland D. Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P. carinii pneumonia in patients with HIV-1: a prospective study. Lancet, 2001, 358, 545–549. [PubMed]
  • [41]Rabodonirina M., Nahimana A., Weber R., Francioli P., Bille J. & Hauser P.M. Geographical variation in the prevalence of Pneumocystis jirovecii dihydropteroate synthase mutations within Western Europe. J Eukaryot Microbiol, 2006, 53 (Suppl 1), S112–113. [PubMed]
  • [42]Radhi S., Alexander T., Ukwu M., Saleh S. & Morris A. Outcome of HIV-associated Pneumocystis pneumonia in hospitalized patients from 2000 through 2003. BMC Infect Dis, 2008, 8, 118. [PubMed]
  • [43]Shimizu Y., Sunaga N., Dobashi K., Fueki M., Fueki N., Makino S. & Mori M. Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study. BMC Infect Dis, 2009, 9, 47. [PubMed]
  • [44]Skelly M., Hoffman J., Fabbri M., Holzman R.S., Clarkson A.B. Jr. & Merali S. S-adenosylmethionine concentrations in diagnosis of Pneumocystis carinii pneumonia. Lancet, 2003, 361, 1267–1268. [PubMed]
  • [45]Skelly M.J., Holzman R.S. & Merali S. S-adenosylmethionine levels in the diagnosis of Pneumocystis carinii pneumonia in patients with HIV infection. Clin Infect Dis, 2008, 46, 467–471. [PubMed]
  • [46]Vidal S., de la Horra C., Martin J., Montes-Cano M.A., Rodriguez E., Respaldiza N., Rodriguez F., Varela J.M., Medrano F.J. & Calderon E.J. Pneumocystis jirovecii colonisation in patients with interstitial lung disease. Clin Microbiol Infect, 2006, 12, 231–235. [PubMed]
  • [47]Walzer P.D., Evans H.E., Copas A.J., Edwards S.G., Grant A.D. & Miller R.F. Early predictors of mortality from Pneumocystis jirovecii pneumonia in HIV-infected patients: 1985–2006. Clin Infect Dis, 2008, 46, 625–633. [PubMed]
  • [48]Watanabe T., Yasuoka A., Tanuma J., Yazaki H., Honda H., Tsukada K., Honda M., Gatanaga H., Teruya K., Kikuchi Y. & Oka S. Serum (1–3)-beta-D-glucan as a noninvasive adjunct marker for the diagnosis of Pneumocystis pneumonia in patients with AIDS. Clin Infect Dis, 2009, 49, 1128–1131. [PubMed]
  • [49]Wissmann G., Alvarez-Martinez M.J., Meshnick S.R., Dihel A.R. & Prolla J.C. Absence of dihydropteroate synthase mutations in Pneumocystis jirovecii from Brazilian AIDS patients. J Eukaryot Microbiol, 2006, 53, 305–307. [PubMed]
  • [50]Worodria W., Davis J.L., Cattamanchi A., Andama A., den Boon S., Yoo S.D., Hopewell P.C. & Huang L. Bronchoscopy is useful for diagnosing smear-negative tuberculosis in HIV-infected patients. Eur Respir J, 2010, 36, 446–448. [PubMed]
  • [51]Worodria W., Okot-Nwang M., Yoo S.D. & Aisu T. Causes of lower respiratory infection in HIV-infected Ugandan adults who are sputum AFB smear-negative. Int J Tuberc Lung Dis, 2003, 7, 117–123. [PubMed]
  • [52]Zolopa A., Andersen J., Powderly W., Sanchez A., Sanne I., Suckow C., Hogg E. & Komarow L. Early antiretroviral therapy reduces AIDS progression/death in individuals with acute opportunistic infections: a multicenter randomized strategy trial. PLoS One, 2009, 4, e5575. [PubMed]
  文献评价指标  
  下载次数:0次 浏览次数:4次