| F1000Research | |
| Explain your data by Concept Profile Analysis Web Services | |
| Marco Roos1  Jan A. Kors2  Erik van Mulligen2  Barend Mons1  Rajaram Kaliyaperumal1  Mark Thompson1  Eelke van der Horst1  Eleni Mina1  Reinout van Schouwen1  Kristina M. Hettne1  | |
| [1] Department of Human Genetics, Leiden University Medical Center, Leiden, 2300 RC, Netherlands;Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, 3000 CA, Netherlands | |
| Others : 869269 DOI : 10.12688/f1000research.4830.1 |
|
PDF
|
|
【 摘 要 】
The Concept Profile Analysis technology (overlapping co-occurring concept sets based on knowledge contained in biomedical abstracts) has led to new biomedical discoveries, and users have been able to interact with concept profiles through the interactive tool “Anni” (http://biosemantics.org/anni). However, Anni provides no way for users to save their procedures, results, or related provenance. Here we present a new suite of Web Service operations that allows bioinformaticians to design and execute their own Concept Profile Analysis workflow, possibly as part of a larger bioinformatics analysis. The source code can be downloaded from ZENODO at http://www.dx.doi.org/10.5281/zenodo.10963.
【 授权许可】
© 2014 Hettne KM et al.This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| 20140729230651245.pdf | 485KB | ||
| Figure 4. Taverna nested workflow for gene annotation. | 68KB | Image | |
| Figure 3. Taverna details window. | 55KB | Image | |
| Figure 2. Taverna run window. | 47KB | Image | |
| Figure 1. Taverna workflow for matching concept(s) with a predefined set of concept profiles. | 51KB | Image |
【 图 表 】
Figure 1. Taverna workflow for matching concept(s) with a predefined set of concept profiles.
Figure 2. Taverna run window.
Figure 3. Taverna details window.
Figure 4. Taverna nested workflow for gene annotation.
【 参考文献 】
- [1] Jelier R, Schuemie MJ, Roes PJ, et al.:Literature-based concept profiles for gene annotation: the issue of weighting.Int J Med Inform.2008; 77(5): 354–362.
- [2] Jelier R, ’t Hoen PA, Sterrenburg E, et al.:Literature-aided meta-analysis of microarray data: a compendium study on muscle development and disease.BMC Bioinformatics.2008; 9: 291.
- [3] van Haagen HH, ’t Hoen PA, de Morrée A, et al.:In silico discovery and experimental validation of new protein-protein interactions.Proteomics.2011; 11(5): 843–853.
- [4] Hettne KM, Boorsma A, van Dartel DA, et al.:Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data.BMC Med Genomics.2013; 6(1): 2.
- [5] Wolstencroft K, Haines R, Fellows D, et al.:The Taverna workflow suite: designing and executing workflows of Web Services on the desktop, web or in the cloud.Nucleic Acids Res.2013; 41(Web Server issue): W557–W561.
- [6] Hettne KM, Wolstencroft K, Belhajjame K, et al.:Best Practices for Workflow Design: How to Prevent Workflow Decay. In Proceedings of SWAT4LS 2012, 2012.
- [7] Hettne KM, Dharuri H, van Schouwen R, et al.:Explaining genome-wide association study results using concept profile analysis and the Kyoto Encyclopedia of Genes and Genomes pathway database. In Proceedings of BioLINK SIG 2013, 2013; page 60.
- [8] Rak R, Batista-Navarro RT, Carter J, et al.:Processing biological literature with customizable web services supporting interoperable formats.Database(oxford).2014; 2014: pii: bau064.
- [9] van der Horst E, Roos M, Hettne K:Workflows and services for concept profile generation.F1000Posters.2014; 5(33).
- [10] Jelier R, Schuemie MJ, Veldhoven A, et al.:Anni 2.0: a multipurpose text-mining tool for the life sciences.Genome Biol.2008; 9(6): R96.
- [11] Hettne KM, van Schouwen R, Mina E, et al.:New suite of Concept Profile Analysis Web Services.ZENODO.2014. Data Source
PDF