Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice

Parasite

and Antonio Muro²  Jesús Pérez-Losada³  Andrés Castellanos³  Purificación Galindo-Villardón¹  Belén Vicente²  Luis Pérez del Villar² 

[1] Departamento de Estadística, Universidad de Salamanca,37008 Salamanca,Spain;Instituto de Investigaciones Biomédicas de Salamanca (IBSAL),Salamanca,Spain;Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC,37008 Salamanca,Spain

关键词: Hematological phenotypes;    Immunological phenotypes;    Mus spretus;    Schistosoma mansoni infection;   

Others  :  808559
DOI  :  doi:10.1051/parasite/2013027

 received in 2013-06-09, accepted in 2013-08-14,  发布年份 2013

【 摘 要 】

Most Schistosoma mansoni experimental infections are developed in several inbred strains of Mus musculus as definitive host. In contrast, Mus spretus is unexplored in Schistosoma infection studies. Mus spretus provides a high variation of immunological phenotypes being an invaluable tool for genetic studies and gene mapping. The aim of this study is to characterize hematological and immunological responses against Schistosoma mansoni infection in Mus spretus (SPRET/EiJ strain) vs. Mus musculus (CD1 strain) mice. Nine weeks after cercarial exposure, animals were perfused and the parasite burden was assessed. The parasitological data suggests that SPRET/EiJ mice tolerate higher parasite loads compared to CD1 strain. In addition, hematological parameters measured in Mus spretus group showed a significant increase in granulocytes population in early stages of infection compared to the CD1 cohort. Meanwhile, CD1 presented higher levels of lymphocytes and IgG1 in the late stages of S. mansoni experimental infection.

【 授权许可】

   
© L. Pérez del Villar et al., published by EDP Sciences, 2013

【 图 表 】

Figure 1.

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