Low antiplasmodial activity of alkaloids and amides from the stem bark of Zanthoxylum rubescens (Rutaceae)

Parasite

and M. Randrianarivelojosia³  P.K. Cheplogoi²  K.D. Tano⁴  D.A. Mulholland¹  L. Penali⁴ 

[1] School of Biomedical and Molecular Sciences, University of Surrey,Guildford,Surrey,GU2 7XH,United Kingdom;Department of Chemistry, Egerton University, P.O. Box 536-20107,Njoro,Kenya;Malaria Research Group, Institut Pasteur de Madagascar,BP 1274,Antananarivo (101),Madagascar;Malariology Department, Institut Pasteur de Côte d’Ivoire,01 BP 490 Abidjan 01,Ivory Coast

关键词: malaria;    bis[6-(5,6-dihydrochelerythrinyl)] ether;    amides;    alkaloids;    Rutaceae;    Zanthoxylum rubescens;   

Others  :  808642
DOI  :  doi:10.1051/parasite/2007142161

 received in 2006-12-18, accepted in 2007-01-17,  发布年份 2007

【 摘 要 】

The stem bark of Zanthoxylum rubescens (syn. Fagara rubescens) is used for treating fevers associated with malaria in the Ivory Coast. Three alkaloids: N-nornitidine, 7,9-dimethoxy-2,3- methylenedioxybenzophenanthridine, and bis[6-(5,6- dihydrochelerythrinyl)] ether; and two amides: zanthomamide and lemairamide, were isolated from the stem bark of this plant. These compounds were screened in vitro against the chloroquine-sensitive 3D7 strain and the chloroquine-resistant FCM29 strain of P. falciparum. N-nornitidine was found to be inactive. 7,9- dimethoxy-2,3-methylenedioxybenzophenanthridine, lemairamide and zanthomamide showed weak activity with average IC50 values ranging from 45.6 μM to 149.9 μM. Bis[6-(5,6- dihydrochelerythrinyl)] ether was the most active of the tested compounds with mean IC50s of 14.9 ± 1.4 μM in FCM29 strain and 15.3 ± 3.4 μM in 3D7 strain (~ 58 to ~ 1130 times less active than chloroquine respectively). The anti-Plasmodium activities of the tested alkaloids of Z. rubescens were low; and do not encourage the use of this plant as antimalarial.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2007