Onchocerciasis control: biological research is still needed

Parasite

M. Boussinesq¹ 

[1] Institut de Recherche pour le Développement (IRD), UR-024, 911, avenue Agropolis,BP 64501,34394 Montpellier Cedex 5,France

关键词: vaccine;    genomics;    resistance;    elimination;    adverse reactions;    ivermectin;    treatment;    Onchocerca volvulus;    onchocerciasis;   

Others  :  808529
DOI  :  doi:10.1051/parasite/2008153510

【 摘 要 】

Achievements obtained by the onchocerciasis control programmes should not lead to a relaxation in the biological research on Onchocerca volvulus. Issues such as the Loa loa-related postivermectin serious adverse events, the uncertainties as to whether onchocerciasis can be eliminated by ivermectin treatments, and the possible emergence of ivermectin-resistant O. volvulus populations should be addressed proactively. Doxycycline, moxidectin and emodepside appear to be promising as alternative drugs against onchocerciasis but support to researches in immunology and genomics should also be increased to develop new control tools, including both vaccines and macrofilaricidal drugs.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2008