Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study

Parasite

and O. Garraud¹  R. Perraut³  P. Flori¹  V. Ndadjimbaye⁶  T.O. Diallo²  K. Doui-Doumgba⁴  J. Ndémanga⁴  F.E. Gbagba⁷  W.S. Nambei⁵ 

[1] GIMAP-EA 3064, Faculté de Médecine, Université Jean Monnet,Saint-Étienne,France;Laboratoire d’Analyses Médicales, Hôpital Communautaire de Bangui,Bangui,Central African Republic;Laboratoire d’Immunologie, Institut Pasteur de Dakar,Sénégal;Service des Urgences Médico-Chirurgicales, Hôpital Amitié de Bangui,Bangui,Central African Republic;Service de Pharmacie, Hôpital Amitié de Bangui,Bangui,Central African Republic;Centre d’Immunologie et de Biologie Parasitaire, Institut Pasteur de Lille,Lille,France;Service des Urgences Médicales, Hôpital Amitié de Bangui,Bangui,Central African Republic

关键词: piperaquine;    Artecom®;    dihydroartemisin;    Africa;    drug;    malaria;   

Others  :  808813
DOI  :  doi:10.1051/parasite/2005121073

 received in 2004-05-17, accepted in 2004-11-11,  发布年份 2005

【 摘 要 】

Drug resistance to Plasmodium falciparum contributes to major health problems in central Africa and, as a consequence, poverty. We have analyzed the efficacy of three currently available antimalarial drugs to treat symptomatic, uncomplicated P. falciparum malaria in semiimmune adults living in Bangui, Central Republic of Africa. 210 consecutive individuals were enrolled in the survey, of which 45 were excluded. Those having received dihydroartemisin proved significantly less parasitemic than those having received quinine per os or sulfadoxin-pyrimethamin (χ2 = 16.93 ; p < 0.05), and 75 % recovered in two days compared to 57 and 44 %, respectively. The 25 % who did not recover benefited from a second cure with dihydroartemisin, which proved 100 % efficient. The most accurate protocol remains to be established by analyzing clinical and parasitological data and taking into account the economics of the country.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2005