Raised D-dimer levels in acute sickle cell crisis and their correlation with chest X-ray abnormalitiesErhöhte D-Dimer-Konzentrationen bei akuten Sichelzellkrisen und ihre Korrelation mit abnormen Röntgenbefunden an der Lunge

GMS German Medical Science — an Interdisciplinary Journal

Imad S. A. Hassan¹  Zivani Chapunduka¹  Taj E. Al Mekki¹  Hilali Hassan¹  Inam Mughal¹  Javeed Dar¹ 

[1] Armed Forces Hospital, Southern Region, Khamis Mushayt, Kingdom of Saudi Arabia

关键词: painful;    lung;    hemoglobinopathy;    coagulation;   

Others  :  869168

实施日期：2010-09-15，发布日期：2010-10-08

【 摘 要 】

Objective: Quantitation of D-dimer level during a sickling crisis and its correlation with other clinical abnormalities.

Design: Prospective longitudinal study.

Setting: Armed Forces Hospital, Southern Region, Kingdom of Saudi Arabia.

Patients: Adult patients (12 years and older) admitted acutely with a sickle cell crisis who consent to taking part in the study. Candidates may re-participate if they are readmitted with a further acute painful crisis.

Results: 36 patients with homozygous sickle cell disease consented to take part in the study. D-dimer levels were raised in 31 (68.9%) of 45 episodes of painful crisis of whom 13 had an abnormal chest X-ray. Of those with a normal chest X-ray only one patient had a raised D-dimer level: sensitivity of 92.3%, specificity 40.6%, positive predictive value 38.7% and negative predictive value of 92.9% for an abnormal chest X-ray.

Conclusion: D-dimer levels are frequently raised during an acute painful crisis.A normal level has a high negative predictive value for an abnormal chest X-ray.

【 授权许可】

   
© 2010 Dar et al.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

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