Identification of mosquito repellent odours from Ocimum forskolei

Particle and Fibre Toxicology

Richard Hopkins²  Robert Glinwood²  Maedot Ghebru³  Rickard Ignell¹  Teun Dekker¹ 

[1] Division of Chemical Ecology, Department of Crop Science, Swedish University of Agricultural Sciences PO 44, Alnarp, SE-23053 Sweden;Department of Ecology, Swedish University of Agricultural Sciences, Box 7044, Uppsala SE-750 07, Sweden;Department of Biology, University of Asmara, Asmara, Eritrea

关键词: methyl salicylate;    methyl cinnamate;    linalool;    repellent;    mosquito;    Aedes aegypti;    GC-EAD;    Lamiaceae;    Ocimum forskolei;   

Others  :  1235349
DOI  :  10.1186/1756-3305-4-183

 received in 2011-05-16, accepted in 2011-09-22,  发布年份 2011

【 摘 要 】

Background

Native mosquito repellent plants have a good potential for integrated mosquito control in local settings. Ocimum forskolei, Lamiaceae, is used in Eritrea as a spatial mosquito repellent inside houses, either through crushing fresh plants or burning dry plants. We verified whether active repellent compounds could be identified using gas-chromatography coupled electroantennogram recordings (GC-EAD) with headspace extracts of crushed plants.

Results

EAD active compounds included (R)-(-)-linalool, (S)-(+)-1-octen-3-ol, trans-caryophyllene, naphthalene, methyl salicylate, (R)-(-)-α-copaene, methyl cinnamate and (E)-ocimene. Of these compounds (R)-(-)-linalool, methyl cinnamate and methyl salicylate reduced landing of female Aedes aegypti on human skin-odor baited tubes. The latter two are novel mosquito repellent compounds.

Conclusions

The identification of mosquito repellent compounds contributes to deciphering the mechanisms underlying repulsion, supporting the rational design of novel repellents. The three mosquito repellent compounds identified in this study are structurally dissimilar, which may indicate involvement of different sensory neurons in repulsion. Repulsion may well be enhanced through combining different repellent plants (or their synthetic mimics), and can be a locally sustainable part in mosquito control efforts.

【 授权许可】

   
2011 Dekker et al; licensee BioMed Central Ltd.

【 图 表 】

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