Pharmacogenetics, pharmacogenomics and airway disease

Respiratory Research

Ian P Hall¹ 

[1] Queens Medical Centre, Nottingham, UK

关键词: single-nucleotide polymorphism;    proteomics;    pharmacogenomics;    pharmacogenetics;    expression profiling;    chronic obstructive pulmonary disease;    asthma;   

Others  :  1227410
DOI  :  10.1186/rr159

 received in 2001-05-08, accepted in 2001-10-23,  发布年份 2001

【 摘 要 】

The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmacogenetics and pharmacogenomics. Considerable inter-individual variation exists at the DNA level in targets for medication, and variability in response to treatment may, in part, be determined by this genetic variation. Increased knowledge about the human genome might also permit the identification of novel therapeutic targets by expression profiling at the RNA (genomics) or protein (proteomics) level. This review describes recent advances in pharmacogenetics and pharmacogenomics with regard to airway disease.

【 授权许可】

   
2002 BioMed Central Ltd

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