The role of surfactant in asthma

Respiratory Research

Jens M Hohlfeld¹ 

[1] Department of Respiratory Medicine, Hannover Medical School and Department of Immunology, Allergology and Clinical Inhalation, Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany

关键词: surfactant function;    innate immunity;    asthma;    allergy;    airways;   

Others  :  1227416
DOI  :  10.1186/rr176

 received in 2001-07-09, accepted in 2001-08-31,  发布年份 2001

【 摘 要 】

Pulmonary surfactant is a unique mixture of lipids and surfactant-specific proteins that covers the entire alveolar surface of the lungs. Surfactant is not restricted to the alveolar compartment; it also reaches terminal conducting airways and is present in upper airway secretions. While the role of surfactant in the alveolar compartment has been intensively elucidated both in health and disease states, the possible role of surfactant in the airways requires further research. This review summarizes the current knowledge on surfactant functions regarding the airway compartment and highlights the impact of various surfactant components on allergic inflammation in asthma.

【 授权许可】

   
2001 BioMed Central Ltd

【 图 表 】

Figure 1.

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