Lack of association between Toxoplasma gondii infection and hypertensive disorders in pregnancy: a case–control study in a Northern Mexican population

Particle and Fibre Toxicology

Oliver Liesenfeld³  Luis Francisco Sánchez-Anguiano¹  Jesús Hernández-Tinoco¹  José M Salas-Pacheco¹  Ada A Sandoval-Carrillo¹  Fernando Vázquez-Alaníz⁴  Cosme Alvarado-Esquivel² 

[1] Institute for Scientific Research “Dr. Roberto Rivera Damm”, Juárez University of Durango State, Avenida Universidad S/N, Durango, Durango 34000, Mexico;Laboratorio de Investigación Biomédica, Facultad de Medicina y Nutrición, Avenida Universidad S/N, Durango 34000, Dgo, Mexico;Present address: Roche Molecular Diagnostics, Pleasanton, CA, USA;Hospital General de Durango, Secretaría de Salud, Avenida 5 de febrero y Norman Fuentes, Durango, Dgo 34000, Mexico

关键词: Epidemiology;    Infection;    Eclampsia;    HELLP syndrome;    Preeclampsia;    Seroprevalence;    Toxoplasma gondii;   

Others  :  807380
DOI  :  10.1186/1756-3305-7-167

 received in 2014-01-13, accepted in 2014-03-30,  发布年份 2014

【 摘 要 】

Background

The outcome of pregnancy is often threatened by hypertension disorders, i.e. eclampsia. Rate of infection with the protozoan parasite Toxoplasma gondii can be as high as 80% in pregnant women, and infection acquired during pregnancy can lead to fetal death. Very little is known about a potential association between infections, i.e. those with Toxoplasma gondii, and hypertensive disorders during pregnancy.

Methods

Through a case–control study design, we investigated the presence of anti-Toxoplasma IgG and anti-Toxoplasma IgM antibodies in 146 pregnant women suffering from hypertensive disorders (cases) and 146 age-matched normotensive pregnant women (controls) attending a public hospital in Durango City, Mexico. Obstetric and blood pressure characteristics from cases and controls were also obtained.

Results

Seroprevalence of anti-Toxoplasma IgG antibodies and IgG titers did not differ significantly in controls (8/146; 5.5%) and cases (9/146; 6.2%). Anti-Toxoplasma IgM antibodies were found in 2 (1.2%) controls and none of the cases. Seroprevalence of T. gondii in controls (5.5%) was similar to seroprevalences found in patients with mild preeclampsia (4/27: 14.8%), severe preeclampsia (5/95: 5.3%), eclampsia (0/16: 0%) and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count) (0/8: 0%) (P = 0.23).

Conclusions

Our results suggest that latent infection with T. gondii is not associated with hypertensive disorders in pregnant women in Northern Mexico. Further studies with larger sample sizes are needed to elucidate the association of infection with T. gondii with hypertensive disorders in pregnancy.

【 授权许可】

   
2014 Alvarado-Esquivel et al.; licensee BioMed Central Ltd.

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