GST-omega genes interact with environmental tobacco smoke on adult level of lung function

Respiratory Research

Judith M Vonk¹  Dirkje S Postma¹  Nick HT ten Hacken¹  H Marike Boezen¹  Kim de Jong¹ 

[1] University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands

关键词: Lung function;    Environmental tobacco smoke;    Genes;   

Others  :  792947
DOI  :  10.1186/1465-9921-14-83

 received in 2013-04-02, accepted in 2013-07-15,  发布年份 2013

【 摘 要 】

Background

Lung growth in utero and lung function loss during adulthood can be affected by exposure to environmental tobacco smoke (ETS). The underlying mechanisms have not been fully elucidated. Both ETS exposure and single nucleotide polymorphisms (SNPs) in Glutathione S-Transferase (GST) Omega genes have been associated with the level of lung function. This study aimed to assess if GSTO SNPs interact with ETS exposure in utero and during adulthood on the level of lung function during adulthood.

Methods

We used cross-sectional data of 8,128 genotyped participants from the LifeLines cohort study. Linear regression models (adjusted for age, sex, height, weight, current smoking, ex-smoking and packyears smoked) were used to analyze the associations between in utero, daily and workplace ETS exposure, GSTO SNPs, the interaction between ETS and GSTOs, and level of lung function (FEV₁, FEV₁/FVC). Since the interactions between ETS and GSTOs may be modified by active tobacco smoking we additionally assessed associations in never and ever smokers separately. A second sample of 5,308 genotyped LifeLines participants was used to verify our initial findings.

Results

Daily and workplace ETS exposure was associated with significantly lower FEV₁ levels. GSTO SNPs (recessive model) interacted with in utero ETS and were associated with higher levels of FEV₁, whereas the interactions with daily and workplace ETS exposure were associated with lower levels of FEV₁, effects being more pronounced in never smokers. The interaction of GSTO2 SNP rs156697 with in utero ETS associated with a higher level of FEV₁ was significantly replicated in the second sample. Overall, the directions of the interactions of in utero and workplace ETS exposure with the SNPs found in the second (verification) sample were in line with the first sample.

Conclusions

GSTO genotypes interact with in utero and adulthood ETS exposure on adult lung function level, but in opposite directions.

【 授权许可】

   
2013 de Jong et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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