Hepatitis C virus genotypes in Pakistan: a systemic review

Virology Journal

Ijaz Ali²  Sanaullah Khan¹  Sobia Attaullah³ 

[1]Kohat University of Science and Technology, Kohat Khyber Pakhtunkhwa, Pakistan

[2]Institution of Biotechnology and Genetic Engineering, KPK Agricultural University Peshawar, Pakistan

[3]Department of Zoology, Islamia College (Public Sector University) Peshawar, Khyber Pakhtunkhwa, Pakistan

关键词: Pakistan;    Prevalence;    Genotypes;    HCV;   

Others  :  1156122
DOI  :  10.1186/1743-422X-8-433

 received in 2011-07-14, accepted in 2011-09-08,  发布年份 2011

【 摘 要 】

Background and aim

Phylogenetic analysis has led to the classification of hepatitis C virus (HCV) into 1-6 major genotypes. HCV genotypes have different biological properties, clinical outcome and response to antiviral treatment and provide important clues for studying the epidemiology, transmission and pathogenesis. This article deepens the current molecular information about the geographical distribution of HCV genotypes and subgenotypes in population of four provinces of Pakistan. 34 published papers (1996-2011) related to prevalence of HCV genotypes/serotypes and subgenotypes in Pakistan were searched.

Result

HCV genotype/s distribution from all 34 studies was observed in 28,400 HCV infected individuals in the following pattern: 1,999 (7.03%) cases of genotype 1; 1,085 (3.81%) cases of genotype 2; 22,429 (78.96%) cases of genotype 3; 453 (1.59%) cases of genotype 4; 29 (0.10%) cases of genotype 5; 37 (0.13%) cases of genotype 6; 1,429 (5.03%) cases of mixed genotypes, and 939 (3.30%) cases of untypeable genotypes. Overall, genotype 3a was the predominant genotype with a rate of 55.10%, followed by genotype 1a, 3b and mixed genotype with a rate of 10.25%, 8.20%, and 5.08%, respectively; and genotypes 4, 5 and 6 were rare. Genotype 3 occurred predominately in all the provinces of Pakistan. Second more frequently genotype was genotype 1 in Punjab province and untypeable genotypes in Sindh, Khyber Pakhtunkhwa and Balochistan provinces.

【 授权许可】

   
2011 Attaullah et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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