Total error shift patterns for daily CT on rails image-guided radiotherapy to the prostate bed

Radiation Oncology

Ron R Allison⁴  Claudio H Sibata³  Helvecio C Mota⁶  Maria C Ferreira²  Jingxia Liu⁵  Hiram A Gay⁷  Ronaldo Cavalieri¹ 

[1] Department of Radiation Oncology, Clínicas Oncológicas Integradas, Rio de Janeiro, Brazil;Department of Radiation Oncology, The Brody School of Medicine, East Carolina University, Greenville, NC, USA;Physics and Engineering Department, 21st Century Oncology, Fort Myers, FL, USA;21st Century Oncology, Greenville, NC, USA;Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA;Department of Radiation Oncology, Carolinas Medical Center - Northeast, Concord, NC, USA;Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA

关键词: prostate bed;    shift total error;    CT on rails;    IGRT;    Post-prostatectomy radiotherapy;   

Others  :  1223873
DOI  :  10.1186/1748-717X-6-142

 received in 2011-07-28, accepted in 2011-10-24,  发布年份 2011

【 摘 要 】

Background

To evaluate the daily total error shift patterns on post-prostatectomy patients undergoing image guided radiotherapy (IGRT) with a diagnostic quality computer tomography (CT) on rails system.

Methods

A total of 17 consecutive post-prostatectomy patients receiving adjuvant or salvage IMRT using CT-on-rails IGRT were analyzed. The prostate bed's daily total error shifts were evaluated for a total of 661 CT scans.

Results

In the right-left, cranial-caudal, and posterior-anterior directions, 11.5%, 9.2%, and 6.5% of the 661 scans required no position adjustments; 75.3%, 66.1%, and 56.8% required a shift of 1 - 5 mm; 11.5%, 20.9%, and 31.2% required a shift of 6 - 10 mm; and 1.7%, 3.8%, and 5.5% required a shift of more than 10 mm, respectively. There was evidence of correlation between the x and y, x and z, and y and z axes in 3, 3, and 3 of 17 patients, respectively. Univariate (ANOVA) analysis showed that the total error pattern was random in the x, y, and z axis for 10, 5, and 2 of 17 patients, respectively, and systematic for the rest. Multivariate (MANOVA) analysis showed that the (x,y), (x,z), (y,z), and (x, y, z) total error pattern was random in 5, 1, 1, and 1 of 17 patients, respectively, and systematic for the rest.

Conclusions

The overall daily total error shift pattern for these 17 patients simulated with an empty bladder, and treated with CT on rails IGRT was predominantly systematic. Despite this, the temporal vector trends showed complex behaviors and unpredictable changes in magnitude and direction. These findings highlight the importance of using daily IGRT in post-prostatectomy patients.

【 授权许可】

   
2011 Cavalieri et al; licensee BioMed Central Ltd.

【 图 表 】

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