3D-image-guided high-dose-rate intracavitary brachytherapy for salvage treatment of locally persistent nasopharyngeal carcinoma

Radiation Oncology

Bi-Xiu Wen¹  Bin S Teh³  Yuan-Hong Gao⁴  Wei-Jun Ye⁴  Jia Xu²  Xin-Ping Cao⁴  Yu-Feng Ren¹ 

[1] Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Rd II, Guangzhou 510080, China;Division of Emergency Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;The Methodist Hospital Research Institute, 6565 Fannin, Houston, Texas 77030, USA;State Key Laboratory of Oncology in Southern China, Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou 510060, China

关键词: Local tumor control;    3D-image-guided HDR Brachytherapy;    Persistent disease;    Intensity-modulated radiotherapy;    Nasopharyngeal carcinoma;   

Others  :  1153563
DOI  :  10.1186/1748-717X-8-165

 received in 2012-12-17, accepted in 2013-05-08,  发布年份 2013

【 摘 要 】

Background

To evaluate the therapeutic benefit of 3D-image-guided high-dose-rate intracavitary brachytherapy (3D-image-guided HDR-BT) used as a salvage treatment of intensity modulated radiation therapy (IMRT) in patients with locally persistent nasopharyngeal carcinoma (NPC).

Methods

Thirty-two patients with locally persistent NPC after full dose of IMRT were evaluated retrospectively. 3D-image-guided HDR-BT treatment plan was performed on a 3D treatment planning system (PLATO BPS 14.2). The median dose of 16 Gy was delivered to the 100% isodose line of the Gross Tumor Volume.

Results

The whole procedure was well tolerated under local anesthesia. The actuarial 5-y local control rate for 3D-image-guided HDR-BT was 93.8%, patients with early-T stage at initial diagnosis had 100% local control rate. The 5-y actuarial progression-free survival and distant metastasis-free survival rate were 78.1%, 87.5%. One patient developed and died of lung metastases. The 5-y actuarial overall survival rate was 96.9%.

Conclusions

Our results showed that 3D-image-guided HDR-BT would provide excellent local control as a salvage therapeutic modality to IMRT for patients with locally persistent disease at initial diagnosis of early-T stage NPC.

【 授权许可】

   
2013 Ren et al.; licensee BioMed Central Ltd.

【 图 表 】

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