“Nonmedical” prescription opioid use in North America: a call for priority action

Substance Abuse Treatment, Prevention, and Policy

Thomas Kerr¹  Pauline Voon² 

[1] Department of Medicine, University of British Columbia, St. Paul’s Hospital, 608-1081 Burrard Street, V6Z 1Y6 Vancouver, BC, Canada;British Columbia Centre for Excellence in HIV/AIDS, St. Paul’s Hospital, 608-1081 Burrard Street, V6Z 1Y6 Vancouver, BC, Canada

关键词: Addiction;    Substance abuse;    Pain;    Diversion;    Prescription drug abuse;    Prescription opioid misuse;    Not-as-prescribed opioid use;    NAPOU;    NMPOU;    Nonmedical prescription opioid use;   

Others  :  833905
DOI  :  10.1186/1747-597X-8-39

 received in 2013-10-12, accepted in 2013-11-26,  发布年份 2013

【 摘 要 】

Nearly four years after the United States Congress heralded a “decade of pain control and research”, chronic pain remains a mounting public health concern worldwide. The escalating prevalence of chronic pain in recent years has been paralleled by a rise in prescription opioid availability, misuse, and associated human and social costs. However, national monitoring surveys in the U.S. and Canada currently fail to differentiate between prescription opioid misuse for the purposes of euphoria versus pain or withdrawal management. Furthermore, there is a lack of evidence-based guidelines for pain management among high-risk individuals, and a glaring lack of education for practitioners in the areas of pain and addiction medicine. Herein we propose multiple avenues for intervention and research in order to mitigate the individual, social and structural problems related to undertreated pain and prescription opioid misuse.

【 授权许可】

   
2013 Voon and Kerr; licensee BioMed Central Ltd.

【 参考文献 】

• [1]U.S. Congress: One HUndred Sixth Congress of the United States of America. H.R. 3244, Title VI, Sec. 1603. Washington: Government Printing Office; 2004.
• [2]Lippe PM: The decade of pain control and research. Pain Med 2000, 1:286.
• [3]Gallagher RM: The pain decade and the public health. Pain Med 2000, 1:283-285.
• [4]The American Academy of Pain Medicine: AAPM Facts and Figures on Pain [Internet]. Chicago (IL): American Academy of Pain Medicine; 2013. http://www.painmed.org/PatientCenter/Facts_on_Pain.aspx webcite
• [5]U.S. Department of Health and Human Services, National Institutes of Health: Pain Management: Fact Sheet. 2010. http://report.nih.gov/nihfactsheets/ViewFactSheet.aspx?csid=57 webcite
• [6]Loeser JD, Melzack R: Pain: an overview. Lancet 1999, 353:1607-1609.
• [7]Vukmir RB: Drug seeking behavior. Am J Drug Alcohol Abuse 2004, 30:551-575.
• [8]Institute of Medicine Report from the Committee on Advancing Pain Research, Care, and Education: Relieving Pain in America, A Blueprint for Transforming Prevention, Care, Education and Research. America: The National Academies Press; 2011.
• [9]Heart Disease and Stroke Statistics: A Report From the American Heart Association. Circulation 2011, 123(e18-e209):20.
• [10]Centers for Disease Control and Prevention: National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention; 2011.
• [11]Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Waldron W, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA: SEER Cancer Statistics Review. In Vintage 2009 Populations. Bethesda, MD: National Cancer Institute; 1975-2009. http://seer.cancer.gov/csr/1975_2009_pops09/ webcite, based on November 2011 SEER data submission, posted to the SEER web site, April 2012
• [12]Van Den Kerkhof EG, Hopman WM, Towheed TE, Anastassiades TP, Goldstein DH: The impact of sampling and measurement on the prevalence of self-reported pain in Canada. Pain Res Manag 2003, 8:157-163.
• [13]Boulanger A, Clark AJ, Squire P, Cui E, Horbay GL: Chronic pain in Canada: have we improved our management of chronic noncancer pain? Pain Res Manag 2007, 12:39-47.
• [14]Moulin DE, Clark AJ, Speechley M, Morley-Forster PK: Chronic pain in Canada–prevalence, treatment, impact and the role of opioid analgesia. Pain Res Manag 2002, 7:179-184.
• [15]Fischer B, Keates A, Buhringer G, Reimer J, Rehm J: Non-medical use of prescription opioids and prescription opioid-related harms: why so markedly higher in North America compared to the rest of the world? Addiction 2013, 1. PMID:23692335 [http://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A webcite+23692335]
• [16]The National Center on Addiction and Substance Abuse (CASA) at Columbia University: Under the Counter: The Diversion and Abuse of Controlled Prescription Drugs in the U.S. New York, NY: CASA Columbia; 2005.
• [17]Canada H: Canadian Alcohol and Drug Use Monitoring Survey 2009. Ottawa, Canada: Health Canada; 2010.
• [18]Shield KD, Jones W, Rehm J, Fischer B: Use and nonmedical use of prescription opioid analgesics in the general population of Canada and correlations with dispensing levels in 2009. Pain Res Manag 2013, 18:69-74.
• [19]Nosyk B, Anglin MD, Brissette S, Kerr T, Marsh DC, Schackman BR, Wood E, Montaner JS: A call for evidence-based medical treatment of opioid dependence in the United States and Canada. Health Aff 2013, 32:1462-1469.
• [20]Fischer B, Lusted A, Roerecke M, Taylor B, Rehm J: The prevalence of mental health and pain symptoms in general population samples reporting nonmedical use of prescription opioids: a systematic review and meta-analysis. J Pain 2012, 13:1029-1044.
• [21]Barry DT, Goulet JL, Kerns RK, Becker WC, Gordon AJ, Justice AC, Fiellin DA: Nonmedical use of prescription opioids and pain in veterans with and without HIV. Pain 2011, 152:1133-1138.
• [22]Becker WC, Fiellin DA, Gallagher RM, Barth KS, Ross JT, Oslin DW: The association between chronic pain and prescription drug abuse in Veterans. Pain Med 2009, 10:531-536.
• [23]Novak SP, Herman-Stahl M, Flannery B, Zimmerman M: Physical pain, common psychiatric and substance use disorders, and the non-medical use of prescription analgesics in the United States. Drug Alcohol Depend 2009, 100:63-70.
• [24]Ives TJ, Chelminski PR, Hammett-Stabler CA, Malone RM, Perhac JS, Potisek NM, Shilliday BB, DeWalt DA, Pignone MP: Predictors of opioid misuse in patients with chronic pain: a prospective cohort study. BMC Health Serv Res 2006, 6:46. BioMed Central Full Text
• [25]Baldacchino A, Gilchrist G, Fleming R, Bannister J: Guilty until proven innocent: a qualitative study of the management of chronic non-cancer pain among patients with a history of substance abuse. Addict Behav 2010, 35:270-272.
• [26]Breitbart W, Rosenfeld B, Passik S, Kaim M, Funesti-Esch J, Stein K: A comparison of pain report and adequacy of analgesic therapy in ambulatory AIDS patients with and without a history of substance abuse. Pain 1997, 72:235-243.
• [27]Davis WR, Johnson BD: Prescription opioid use, misuse, and diversion among street drug users in New York City. Drug Alcohol Depend 2008, 92:267-276.
• [28]Substance abuse and mental health services administration: Results from the 2012 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-46, HHS Publication No. (SMA) 13-4795. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2013.
• [29]Fischer B, Nakamura N, Ialomiteanu A, Boak A, Rehm J: Assessing the prevalence of nonmedical prescription opioid use in the general Canadian population: methodological issues and questions. Can J Psychiatry 2010, 55:606-609.
• [30]Boyd CJ, McCabe SE: Coming to terms with the nonmedical use of prescription medications. Subst Abuse Treat Prev Policy 2008, 3:22. BioMed Central Full Text
• [31]McCabe SE, Boyd CJ, Cranford JA, Teter CJ: Motives for nonmedical use of prescription opioids among high school seniors in the United States: self-treatment and beyond. Arch Pediatr Adolesc Med 2009, 163:739-744.
• [32]Rosenblum A, Parrino M, Schnoll SH, Fong C, Maxwell C, Cleland CM, Magura S, Haddox JD: Prescription opioid abuse among enrollees into methadone maintenance treatment. Drug Alcohol Depend 2007, 90:64-71.
• [33]Sullivan MD, Edlund MJ, Zhang L, Unutzer J, Wells KB: Association between mental health disorders, problem drug use, and regular prescription opioid use. Arch Intern Med 2006, 166:2087-2093.
• [34]Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, Davies P, Donovan MI, Fishbain DA, Foley KM, Fudin J, et al.: Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain 2009, 10:113-130.
• [35]Noble M, Treadwell JR, Tregear SJ, Coates VH, Wiffen PJ, Akafomo C, Schoelles KM: Long-term opioid management for chronic noncancer pain. Cochrane Database Syst Rev 2010, CD006605:1.
• [36]Wood E, Samet JH, Volkow ND: Physician education in addiction medicine. Jama 2013, 310:1673-1674.
• [37]Ross-Durow PL, McCabe SE, Boyd CJ: Adolescents’ access to their own prescription medications in the home. J Adolesc Health 2013, 53:260-264.
• [38]Salinas GD, Robinson CO, Abdolrasulnia M: Primary care physician attitudes and perceptions of the impact of FDA-proposed REMS policy on prescription of extended-release and long-acting opioids. J Pain Res 2012, 5:363-369.