Impact of rhinitis on airway inflammation: biological and therapeutic implications

Respiratory Research

Giorgio Walter Canonica¹  Giovanni Passalacqua¹ 

[1] Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy

关键词: united airways;    sinusitis;    rhinitis;    inflammation;    asthma;   

Others  :  1227424
DOI  :  10.1186/rr80

 received in 2001-05-09, accepted in 2001-07-25,  发布年份 2001

【 摘 要 】

There is increasing evidence for a close link between the upper and the lower respiratory tracts and the fact that rhinitis has an important impact on asthma. Several clinical and experimental observations suggest a similar immunopathology between the upper and lower airways in allergic subjects. The common inflammatory process that develops in the respiratory tract explains some of the complex interactions among different clinical diseases such as rhinitis, sinusitis, asthma, bronchial hyperresponsiveness and viral infections. There are also non-inflammatory mechanisms that may contribute to the link between rhinitis and asthma. Moreover, the outcomes of various pharmacological treatments of rhinitis have recently provided further support for the hypothesis of the united airways. We discuss some of the recent observations on the nose-lung interaction and some of the novel therapeutic approaches used to treat rhinitis and asthma that arise from this.

【 授权许可】

   
2001 2001 BioMed Central Ltd

【 图 表 】

Figure 1.

Figure 2.

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