Pulmonary benign metastasizing leiomyoma from uterine leiomyoma

World Journal of Surgical Oncology

Haiquan Chen¹  Lei Shen¹  Jianhua Zhou¹  Yufan Cheng¹  Hong Hu¹  Jie Zhang¹  Yawei Zhang¹  Sufeng Chen¹ 

[1]Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong’an Road, Shanghai 200032, China

关键词: Rare diseases;    Pulmonary;    Metastasis;    Castration;    Benign neoplasms;   

Others  :  1204413
DOI  :  10.1186/1477-7819-11-163

 received in 2012-07-12, accepted in 2013-07-07,  发布年份 2013

【 摘 要 】

Background

Benign metastasizing leiomyoma (BML) occurs in a low proportion of uterine leiomyomas and treatment methods for BML are diverse and controversial. The study introduces preliminary experiences in the diagnosis and treatment of BML with the purpose of finding a suitable management strategy for these patients.

Methods

Three patients with BML were treated in our department from April 2008 to July 2012. Each of these patients presented with multiple nodules in both lungs, where we performed video-assisted thoracoscopic wedge resection to harvest enough tissue for histopathologic and immunohistochemical examination. The patients were treated with medical castration or surgical castration after the diagnosis of BML.

Results

The ultimate pathologic results ruled out the possibility of leiomyosarcoma and other metastatic diseases, and confirmed that the pulmonary lesions were BML. The lung lesions remained stable in two patients who were treated by surgical castration, and the lung nodules regressed in one patient treated with gonadotropin-releasing hormone analogues.

Conclusions

The diagnosis of BML is based on the medical history of uterine myomas and histopathologic and immunohistochemical examination of lung nodules. Video-assisted thoracoscopic wedge resection is the best way to harvest tissue for diagnosis. The better outcomes in BML seem to call for medical intervention, either chemical or surgical, after diagnosis is made.

【 授权许可】

   
2013 Chen et al.; licensee BioMed Central Ltd.

【 图 表 】

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