Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study

Radiation Oncology

Christian M Beauséjour²  Philippe Robaey³  Afshin Hatami³  Caroline Laverdière³  Chloé Langlois-Pelletier³  Oanh NL Le¹  Sophie Marcoux³ 

[1] Centre de recherche du CHU Sainte-Justine, Montréal, Québec, Canada;CHU Sainte-Justine, 3175 Chemin de la Côte-Ste-Catherine, Montréal H3T 1C5, Québec, Canada;Faculté de médecine, Université de Montréal, Montréal, Québec, Canada

关键词: Cancer treatment long-term sequelae;    Childhood acute lymphoblastic leukemia;    p16^INK4a expression;    Cellular senescence;    Ionizing radiation;   

Others  :  1152541
DOI  :  10.1186/1748-717X-8-252

 received in 2013-07-10, accepted in 2013-10-26,  发布年份 2013

【 摘 要 】

Background

Most childhood cancer survivors will develop ionizing radiation treatment-related health conditions that, in many instances, resemble age-associated pathologies. Treatment-induced premature senescence could be an underlying mechanism.

Findings

Here we wanted to know whether the expression of p16^INK4a, a senescence/aging biomarker, is increased in skin biopsies of acute lymphoblastic leukemia survivors (ALL), previously exposed to chemotherapy and radiation therapy. Several years post-treatments, we found p16^INK4a mRNA levels are 5.8 times higher in scalp skin biopsies (targeted by cranial irradiation therapy) compared to buttocks skin biopsies (n = 10, p = 0.01).

Conclusions

These results demonstrate for the first time that premature senescence is induced in pediatric cancer survivors and that p16^INK4a expression could be used as a potential biomarker in this population.

【 授权许可】

   
2013 Marcoux et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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