Effects of oral adenosine-5′-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men

Nutrition & Metabolism

John A Rathmacher⁴  Stephanie MC Wilson³  Shawn M Baier²  Eduardo O De Souza¹  John C Fuller²  Anssi H Manninen⁶  Christopher M Lockwood⁵  Michael D Roberts⁸  Ryan P Lowery⁷  Jordan M Joy⁷  Jacob M Wilson⁷ 

[1] Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil;Metabolic Technologies Inc., Iowa State University Research Park, Ames, IA, USA;Department of Nutrition, IMG Academy, Bradenton, FL, USA;Department of Animal Science, Iowa State University, Ames, IA, USA;AP Nutrition, LLC, Missoula MT, USA;Metabolia Oulu, Oulu, Finland;Department of Health Sciences and Human Performance, The University of Tampa, Tampa FL, USA;Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA

关键词: Sports nutrition;    Muscle hypertrophy;    Strength;    Power;    Exercise performance;    Adenosine triphosphate;   

Others  :  803201
DOI  :  10.1186/1743-7075-10-57

 received in 2013-06-19, accepted in 2013-09-13,  发布年份 2013

【 摘 要 】

Background

Currently, there is a lack of studies examining the effects of adenosine-5′-triphosphate (ATP) supplementation utilizing a long-term, periodized resistance-training program (RT) in resistance-trained populations. Therefore, we investigated the effects of 12 weeks of 400 mg per day of oral ATP on muscular adaptations in trained individuals. We also sought to determine the effects of ATP on muscle protein breakdown, cortisol, and performance during an overreaching cycle.

Methods

The study was a 3-phase randomized, double-blind, and placebo- and diet-controlled intervention. Phase 1 was a periodized resistance-training program. Phase 2 consisted of a two week overreaching cycle in which volume and frequency were increased followed by a 2-week taper (Phase 3). Muscle mass, strength, and power were examined at weeks 0, 4, 8, and 12 to assess the chronic effects of ATP; assessment performance variables also occurred at the end of weeks 9 and 10, corresponding to the mid and endpoints of the overreaching cycle.

Results

There were time (p < 0.001), and group x time effects for increased total body strength (+55.3 ± 6.0 kg ATP vs. + 22.4 ± 7.1 kg placebo, p < 0.001); increased vertical jump power (+ 796 ± 75 ATP vs. 614 ± 52 watts placebo, p < 0.001); and greater ultrasound determined muscle thickness (+4.9 ± 1.0 ATP vs. (2.5 ± 0.6 mm placebo, p < 0.02) with ATP supplementation. During the overreaching cycle, there were group x time effects for strength and power, which decreased to a greater extent in the placebo group. Protein breakdown was also lower in the ATP group.

Conclusions

Our results suggest oral ATP supplementation may enhance muscular adaptations following 12-weeks of resistance training, and prevent decrements in performance following overreaching. No statistically or clinically significant changes in blood chemistry or hematology were observed.

Trial registration

ClinicalTrials.gov NCT01508338

【 授权许可】

   
2013 Wilson et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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