Induction chemotherapy with paclitaxel and cisplatin to concurrent radiotherapy and weekly paclitaxel in the treatment of loco-regionally advanced, stage IV (M0), head and neck squamous cell carcinoma. Mature results of a prospective study

Radiation Oncology

Vincenzo Adamo¹  Nicola Settineri³  Giusy RR Ricciardi¹  Pina Ferraro¹  Nerina Denaro¹  Tindara Franchina¹  Barbara Adamo¹  Anna Santacaterina⁴  Stefano Pergolizzi² 

[1] Department of Human Pathology, Division of Medical Oncology, University of Messina, Messina, Italy;Department of Radiological Science, University of Messina, Messina, Italy;Operative Unit of Medical Physics, Azienda Ospedali Riuniti Papardo-Piemonte, Messina, Italy;Operative Unit of Radiation Oncology, Azienda Ospedali Riuniti Papardo-Piemonte, Messina, Italy

关键词: Radiotherapy;    Head and neck cancer;    Induction Chemotherapy;    Chemoradiation;   

Others  :  1160936
DOI  :  10.1186/1748-717X-6-162

 received in 2011-06-26, accepted in 2011-11-22,  发布年份 2011

【 摘 要 】

Background

to evaluate activity and toxicity of a sequential treatment in advanced, non metastatic, mostly unresectable, head and neck squamous cell carcinoma.

Methods

Patients with loco-regionally advanced or unresectable, head and neck cancer, were prospectively treated with 3 courses of induction chemotherapy followed by concurrent chemoradiation. Induction chemotherapy consisted of paclitaxel 175 mg/m2 day 1 and cisplatin 75 mg/m2 day 2, given every 3 weeks, to a total of three courses. Curative radiotherapy started 4 weeks after the last cycle of chemotherapy with the goal of delivering a total dose ≥ 66 Gy. During RT weekly paclitaxel (40 mg/m2) was administered.

Results

The trial accrued 43 patients from January 1999 to December 2002. All patients received 3 courses of induction chemotherapy and the planned dose of radiotherapy. Thirty-eight patients were able to tolerate weekly paclitaxel during irradiation at least for 4 courses. After induction therapy there were 32 overall responses, 74.4% (23 partial and 9 complete); at completion of concomitant treatment overall responses were 42, 97.7% (20 partial and 22 complete). Median time to treatment failure was 20 months and the disease progression rate at 3 and 5 years was 33% and 23%, respectively. The median overall survival time was 24 months and 3 and 5 years overall survival rates were 37% and 26%, respectively. The major toxicity was mucositis.

Conclusions

This combined treatment was found to be feasible and active in advanced or unresectable, head and neck squamous cell carcinoma patients. Long-term results observed in this trial encourage to consider this approach in further investigation using newer radiation delivering technique and new molecularly agents.

【 授权许可】

   
2011 Pergolizzi et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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