VIRAPOPS2 supports the influenza virus reassortments

Source Code for Biology and Medicine

Anne Vanet²  Michel Petitjean¹ 

[1] MTI, INSERM UMR-S 973, F-75013 Paris, France;Atelier de Bio Informatique, F-75005 Paris, France

关键词: Segmented genomes;    Population genetics;    Simulator;    Virology;   

Others  :  1146063
DOI  :  10.1186/1751-0473-9-18

 received in 2014-07-24, accepted in 2014-08-07,  发布年份 2014

【 摘 要 】

Background

For over 400 years, due to the reassortment of their segmented genomes, influenza viruses evolve extremely quickly and cause devastating epidemics. This reassortment arises because two flu viruses can infect the same cell and therefore the new virions’ genomes will be composed of segment reassortments of the two parental strains. A treatment developed against parents could then be ineffective if the virions’ genomes are different enough from their parent’s genomes. It is therefore essential to simulate such reassortment phenomena to assess the risk of apparition of new flu strain.

Findings

So we decided to upgrade the forward simulator VIRAPOPS, containing already the necessary options to handle non-segmented viral populations. This new version can mimic single or successive reassortments, in birds, humans and/or swines. Other options such as the ability to treat populations of positive or negative sense viral RNAs, were also added. Finally, we propose output options giving statistics of the results.

Conclusion

In this paper we present a new version of VIRAPOPS which now manages the viral segment reassortments and the negative sense single strain RNA viruses, these two issues being the cause of serious public health problems.

【 授权许可】

   
2014 Petitjean and Vanet; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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