Postprandial triglyceride response in normolipidemic, hyperlipidemic and obese subjects – the influence of polydextrose, a non-digestible carbohydrate

Nutrition Journal

Tommi Vasankari⁶  Julian Stowell³  Markku Ahotupa²  Esa Alhoniemi⁵  Nina Rautonen¹  Kirsti Tiihonen⁴ 

[1] Danisco Health and Nutrition, Kantvik, Finland;MCA Research Laboratory, University of Turku, Turku, Finland;DuPont Nutrition and Health, Reigate, UK;DuPont Nutrition and Health, Active Nutrition, Sokeritehtaantie 20, Kantvik, Finland;Avoltus Oy, Turku, Finland;UKK Institute for Health Promotion Research, Tampere, Finland

关键词: Dietary fiber;    Obesity;    Hypertriglyceridemia;    Hyperlipidemia;    Postprandial triglycerides;   

Others  :  1139689
DOI  :  10.1186/s12937-015-0009-0

 received in 2014-10-14, accepted in 2015-02-13,  发布年份 2015

【 摘 要 】

Background

Three independent trials were conducted to evaluate postprandial triglyceride (TG) responses in subjects with different lipid metabolism. The effect of polydextrose (PDX), a soluble non-digestible carbohydrate, on postprandial response was also studied using practically relevant, high fat meal interventions.

Methods

A total of 19 normolipidemic (average BMI 24.1 kg/m²), 21 overweight/hyperlipidemic (average BMI 29.6 kg/m²) and 18 obese/non-diabetic subjects (average BMI 33.6 kg/m²) were included in the study. On two separate occasions all subjects ate two high-fat meals (4293 kJ, 36% from fat), one with PDX (either 12.5 g or 15 g) and one without PDX during placebo-controlled, double-blind, crossover and randomized trials. To obtain the triglyceride measurements venous blood samples were taken before the consumption of the test meal and five times afterwards, up to 6 h post-test meal. The triglyceride responses were modeled using a mixed-effects linear model.

Results

The key variables that explain the variation of the postprandial triglyceride response in the different subject groups were: baseline triglyceride concentration, time point, and PDX vs. placebo treatment (p < 0.05). The maximum postprandial TG concentration was more pronounced in hyperlipidemic group compared to normolipidemic (p < 0.001) or obese groups (p < 0.01). The modeled TG response analysis showed that irrespective of the study population PDX supplementation was one of the factors significantly reducing triglyceride response compared to the placebo treatment (p < 0.05).

Conclusions

Subjects with elevated fasting triglyceride levels display exaggerated and prolonged postprandial triglyceride responses. PDX, a soluble non-digestible carbohydrate, may offer a dietary concept for reducing the postprandial triglyceride response after the consumption of a meal containing a high concentration of fat.

【 授权许可】

   
2015 Tiihonen et al.; licensee BioMed Central.

【 图 表 】

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