Relationship between angiotensin I-converting enzyme insertion/deletion gene polymorphism and retinal vein occlusion

Thrombosis Journal

Yusuf Özertürk¹  Cevat Kirma³  Ahmet Elbay²  Cem Doğan³  Ali Elveran³  Vecih Oduncu³  Tahir Bezgin³  Ali Karagöz³  Işıl Kutluturk¹ 

[1] Kartal Dr. Lütfi Kırdar Training & Research Hospital, Department of Ophthalmology, 34846 İstanbul, Turkey;Pendik State Hospital, Ophthalmology Clinic, İstanbul, Turkey;Kartal Kosuyolu Heart & Research Hospital, Department of Cardiology, Denizer Cad. Cevizli, Kartal-34846 İstanbul, Turkey

关键词: Polymorphism;    Angiotensin I-converting enzyme;    Retinal vein occlusion;   

Others  :  1132754
DOI  :  10.1186/1477-9560-12-17

 received in 2014-01-28, accepted in 2014-07-06,  发布年份 2014

【 摘 要 】

To evaluate the association between angiotensin I-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and retinal vein occlusion (RVO). A total of 80 patients with retinal vein occlusion who was admitted to the Eye Department of Kartal Training and Research Hospital between 2008 and 2011, and 80 subjects were enrolled in this retrospective case–control study. Patients who experienced RVO within one week to six months of study enrolment were included, and those with coronary artery diseases, prior myocardial infarction history and coagulation disturbances were excluded from the study. The diagnosis was made by ophthalmoscopic fundus examination and fluorescein angiography. The ACE gene I/D polymorphism was determined by polymerase chain reaction, and the ACE gene was classified into three types: I/I, I/D and D/D. In multivariate logistic regression analysis, ACE D/D genotype (p = 0.035), diabetes-mellitus (p = 0.019) and hypertension (p = 0.001) were found to be independent predictive factors for RVO. The results of the present study reveal that ACE D/D polymorphism is an independent predictive factor for RVO. However, one cannot definitely conclude that ACE gene polymorphism is a risk factor for retinal vein occlusion.

【 授权许可】

   
2014 Kutluturk et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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