Bayesian geostatistical modelling of soil-transmitted helminth survey data in the People’s Republic of China

Particle and Fibre Toxicology

Penelope Vounatsou¹  Jürg Utzinger¹  Xiao-Nong Zhou²  Ying-Si Lai¹ 

[1] University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland;National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, People’s Republic of China

关键词: People’s Republic of China;    Bayesian geostatistics;    Hookworm;    Trichuris trichiura;    Ascaris lumbricoides;    Soil-transmitted helminths;   

Others  :  823477
DOI  :  10.1186/1756-3305-6-359

 received in 2013-10-04, accepted in 2013-12-04,  发布年份 2013

【 摘 要 】

Background

Soil-transmitted helminth infections affect tens of millions of individuals in the People’s Republic of China (P.R. China). There is a need for high-resolution estimates of at-risk areas and number of people infected to enhance spatial targeting of control interventions. However, such information is not yet available for P.R. China.

Methods

A geo-referenced database compiling surveys pertaining to soil-transmitted helminthiasis, carried out from 2000 onwards in P.R. China, was established. Bayesian geostatistical models relating the observed survey data with potential climatic, environmental and socioeconomic predictors were developed and used to predict at-risk areas at high spatial resolution. Predictors were extracted from remote sensing and other readily accessible open-source databases. Advanced Bayesian variable selection methods were employed to develop a parsimonious model.

Results

Our results indicate that the prevalence of soil-transmitted helminth infections in P.R. China considerably decreased from 2005 onwards. Yet, some 144 million people were estimated to be infected in 2010. High prevalence (>20%) of the roundworm Ascaris lumbricoides infection was predicted for large areas of Guizhou province, the southern part of Hubei and Sichuan provinces, while the northern part and the south-eastern coastal-line areas of P.R. China had low prevalence (<5%). High infection prevalence (>20%) with hookworm was found in Hainan, the eastern part of Sichuan and the southern part of Yunnan provinces. High infection prevalence (>20%) with the whipworm Trichuris trichiura was found in a few small areas of south P.R. China. Very low prevalence (<0.1%) of hookworm and whipworm infections were predicted for the northern parts of P.R. China.

Conclusions

We present the first model-based estimates for soil-transmitted helminth infections throughout P.R. China at high spatial resolution. Our prediction maps provide useful information for the spatial targeting of soil-transmitted helminthiasis control interventions and for long-term monitoring and surveillance in the frame of enhanced efforts to control and eliminate the public health burden of these parasitic worm infections.

【 授权许可】

   
2013 Lai et al.; licensee BioMed Central Ltd.

【 图 表 】

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