A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial

Nutrition Journal

Yukihito Higashi²  Shigeki Satomi¹  Shohei Yamada¹  Noriya Masamura³  Hiroshi Sawada³  Nobuaki Tsuge³  Hideki Nakayama¹ 

[1] Research & Development Institute, House Foods Corporation, Yotsukaido 284-0033, Japan;Department of Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan;Central Research & Development Institute, House Foods Group Inc., Yotsukaido 284-0033, Japan

关键词: Cardiovascular events;    Prevention;    Flow-mediated vasodilation;    Postprandial hyperglycemia;    Endothelial function;    Antioxidant;    Spice;    Curry;   

Others  :  800974
DOI  :  10.1186/1475-2891-13-67

 received in 2013-12-19, accepted in 2014-06-24,  发布年份 2014

【 摘 要 】

Background

Curry, one of the most popular foods in Japan, contains spices that are rich in potentially antioxidative compounds, such as curcumin and eugenol. Oxidative stress is thought to impair endothelial function associated with atherosclerosis, a leading cause of cardiovascular events. The aim of this study was to determine whether a single consumption of curry meal would improve endothelial function in healthy men.

Methods

Fourteen healthy male subjects (BMI 23.7 ± 2.7 kg/m²; age 45 ± 9 years) were given a single serving of curry meal or spice-free control meal (180 g of curry or control and 200 g of cooked rice; approximately 500 kcal in total) in a randomized, controlled crossover design. Before and 1 hr after the consumption, fasting and postprandial flow-mediated vasodilation (FMD) responses and other parameters were measured.

Results

The consumption of the control meal decreased FMD from 5.8 ± 2.4% to 5.1 ± 2.3% (P = 0.039). On the other hand, the consumption of the curry meal increased FMD from 5.2 ± 2.5% to 6.6 ± 2.0% (P = 0.001), and the postprandial FMD after the curry meal was higher than that after the control meal (P = 0.002). Presence of spices in the curry did not alter significantly the systemic and forearm hemodynamics, or any biochemical parameters including oxidative stress markers measured.

Conclusions

These findings suggest that the consumption of curry ameliorates postprandial endothelial function in healthy male subjects and may be beneficial for improving cardiovascular health.

Trial registration

UMIN Clinical Trials Registry000012012.

【 授权许可】

   
2014 Nakayama et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Sen CT: Curry: A Global History. London: Reaktion Books; 2009.
• [2]Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P, Patumraj S: Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med 2010, 10:57.
• [3]Esatbeyoglu T, Huebbe P, Ernst IMA, Chin D, Wagner AE, Rimbach G: Curcumin–from molecule to biological function. Angew Chem Int Ed 2012, 51:5308-5332.
• [4]Damiani CEN, Rossoni LV, Vassallo DV: Vasorelaxant effects of eugenol on rat thoracic aorta. Vascul Pharmacol 2003, 40:59-66.
• [5]Zin WA, Silva AGLS, Magalhaes CB, Carvalho GMC, Riva DR, Lima CC, Leal-Cardoso JH, Takiya CM, Valenca SS, Saldiva PHN, Faffe DS: Eugenol attenuates pulmonary damage induced by diesel exhaust particles. J Appl Physiol 2011, 112:911-917.
• [6]Ng TP, Niti M, Yap KB, Tan WC: Curcumins-rich curry diet and pulmonary function in Asian older adults. PLoS One 2012, 7:e51753.
• [7]Ng T-P, Chiam P-C, Lee T, Chua H-C, Lim L, Kua E-H: Curry consumption and cognitive function in the elderly. Am J Epidemiol 2006, 164:898-906.
• [8]Coutinho M, Gerstein HC, Wang Y, Yusuf S: The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care 1999, 22:233-240.
• [9]Mah E, Bruno RS: Postprandial hyperglycemia on vascular endothelial function: mechanisms and consequences. Nutr Res N Y N 2012, 32:727-740.
• [10]Ceriello A: New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care 2003, 26:1589-1596.
• [11]Lacroix S, Rosiers CD, Tardif J-C, Nigam A: The role of oxidative stress in postprandial endothelial dysfunction. Nutr Res Rev 2012, 25:288-301.
• [12]Kawano H, Motoyama T, Hirashima O, Hirai N, Miyao Y, Sakamoto T, Kugiyama K, Ogawa H, Yasue H: Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 1999, 34:146-154.
• [13]Suzuki K, Watanabe K, Futami-Suda S, Yano H, Motoyama M, Matsumura N, Igari Y, Suzuki T, Nakano H, Oba K: The effects of postprandial glucose and insulin levels on postprandial endothelial function in subjects with normal glucose tolerance. Cardiovasc Diabetol 2012, 11:98.
• [14]Lefèbvre PJ, Scheen AJ: The postprandial state and risk of cardiovascular disease. Diabet Med J Br Diabet Assoc 1998, 15(Suppl 4):S63-S68.
• [15]O’Keefe JH, Gheewala NM, O’Keefe JO: Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol 2008, 51:249-255.
• [16]Node K, Inoue T: Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovasc Diabetol 2009, 8:23.
• [17]Soga J, Noma K, Hata T, Hidaka T, Fujii Y, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y, for the ROCK Study Group: Rho-Associated Kinase Activity, Endothelial Function, and Cardiovascular Risk Factors. Arterioscler Thromb Vasc Biol 2011, 31:2353-2359.
• [18]Kotani K, Maekawa M, Kanno T, Kondo A, Toda N, Manabe M: Distribution of immunoreactive malondialdehyde-modified low-density lipoprotein in human serum. Biochim Biophys Acta 1994, 1215:121-125.
• [19]Devaraj S, Hirany SV, Burk RF, Jialal I: Divergence between LDL oxidative susceptibility and urinary F2-isoprostanes as measures of oxidative stress in type 2 diabetes. Clin Chem 2001, 47:1974-1979.
• [20]Faul F, Erdfelder E, Lang A-G, Buchner A: G* power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007, 39:175-191.
• [21]Engler MB, Engler MM, Chen CY, Malloy MJ, Browne A, Chiu EY, Kwak H-K, Milbury P, Paul SM, Blumberg J, Mietus-Snyder ML: Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr 2004, 23:197-204.
• [22]Hall WL, Formanuik NL, Harnpanich D, Cheung M, Talbot D, Chowienczyk PJ, Sanders TA: A meal enriched with soy isoflavones increases nitric oxide-mediated vasodilation in healthy postmenopausal women. J Nutr 2008, 138:1288-1292.
• [23]Hamilton SJ, Chew GT, Watts GF: Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care 2009, 32:810-812.
• [24]Pfeuffer M, Auinger A, Bley U, Kraus-Stojanowic I, Laue C, Winkler P, Rüfer CE, Frank J, Bösch-Saadatmandi C, Rimbach G, Schrezenmeir J: Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammatory parameters in men with different APOE isoforms. Nutr Metab Cardiovasc Dis NMCD 2011, 23:403-409.
• [25]Crapo PA, Reaven G, Olefsky J: Postprandial plasma-glucose and -insulin responses to different complex carbohydrates. Diabetes 1977, 26:1178-1183.
• [26]Mah E, Noh SK, Ballard KD, Matos ME, Volek JS, Bruno RS: Postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing asymmetric dimethylarginine:arginine. J Nutr 2011, 141:1961-1968.
• [27]Fang X-D, Yang F, Zhu L, Shen Y-L, Wang L-L, Chen Y-Y: Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol 2009, 36:1177-1182.
• [28]Suri S, Liu XH, Rayment S, Hughes DA, Kroon PA, Needs PW, Taylor MA, Tribolo S, Wilson VG: Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol 2010, 159:566-575.
• [29]Rudolph TK, Ruempler K, Schwedhelm E, Tan-Andresen J, Riederer U, Böger RH, Maas R: Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial. Am J Clin Nutr 2007, 86:334-340.
• [30]Raitakari OT, Lai N, Griffiths K, McCredie R, Sullivan D, Celermajer DS: Enhanced peripheral vasodilation in humans after a fatty meal. J Am Coll Cardiol 2000, 36:417-422.
• [31]Järvisalo MJ, Rönnemaa T, Volanen I, Kaitosaari T, Kallio K, Hartiala JJ, Irjala K, Viikari JSA, Simell O, Raitakari OT: Brachial artery dilatation responses in healthy children and adolescents. Am J Physiol Heart Circ Physiol 2002, 282:H87-H92.
• [32]Jazuli F, Pyke KE: The impact of baseline artery diameter on flow-mediated vasodilation: a comparison of brachial and radial artery responses to matched levels of shear stress. Am J Physiol Heart Circ Physiol 2011, 301:H1667-H1677.
• [33]Skulas-Ray AC, Kris-Etherton PM, Teeter DL, Chen C-YO, Vanden Heuvel JP, West SG: A high antioxidant spice blend attenuates postprandial insulin and triglyceride responses and increases some plasma measures of antioxidant activity in healthy, overweight men. J Nutr 2011, 141:1451-1457.
• [34]Berry MK, Russo A, Wishart JM, Tonkin A, Horowitz M, Jones KL: Effect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects. Am J Physiol Gastrointest Liver Physiol 2003, 284:G655-G662.