Kinetic stability of all-in-one parenteral nutrition admixtures in the presence of high dose Ca2+ additive under clinical application circumstances

Nutrition Journal

Romána Zelkó¹  Ferenc Csempesz³  Barnabás Szabó¹  Judith Balogh¹  István G Télessy² 

[1] University Pharmacy Department of Pharmacy Administration, Semmelweis University, 1092, Budapest, Hőgyes E. Street 7-9, Hungary;MedBioFit Research & Organization L.p.c, Fácán Street 25, 2100, Gödöllö, Hungary;Department of Colloid Chemistry and Technology, Eötvös L. University, Pázmány Péter Avenue 1/C, 1117, Budapest, Hungary

关键词: Droplet size distribution;    All-in-one parenteral nutrition admixture;    Kinetic stability;   

Others  :  825641
DOI  :  10.1186/1475-2891-11-32

 received in 2012-02-29, accepted in 2012-05-16,  发布年份 2012

【 摘 要 】

Background

TPN infusions are usually administered during a treatment period of 10–24 hours per day due to the metabolic capacity of the liver. During this time interval physicochemically stable TPN solution (emulsion) is needed for the treatment. The purpose of the present study was to examine how the kinetic stability features of ready-made total parenteral nutrition admixtures containing olive oil and soybean oil will change under the usage-modeling 24-hour application with and without overdose Ca²⁺.

Methods

Particle size analysis and zeta potential measurements were carried out to evaluate the possible changes in the kinetic stability of the emulsions.

Results

Our results indicate that in two of the four mixtures bimodal droplet-size distribution figures were detected and appearance of fat particles over 5 μm can not be disclosed. The tendency for separation of large diameter droplets in the two types of oil-based emulsion systems was different. In case of soybean containing emulsion second peak of droplets appeared in the bottom of the container in contrast to the olive oil containing emulsions where the second peak appeared in the surface layer. Interestingly this phenomenon is independent of calcium-content.

Conclusions

From therapeutic point the emulsions of the bigger droplets containing upper layer are safer because the potentially dangerous big droplets could remain in the infusion bag after the administration.

【 授权许可】

   
2012 Télessy et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

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