Febrile neutropenia: significance of elaborated screening for respiratory viruses, and the comparison of different sampling methods, in neutropenic patients with hematological malignancies

Virology Journal

Caroline E Visser¹  Menno D de Jong¹  Richard Molenkamp¹  Sylvie M Koekkoek¹  Janke Schinkel¹  Bart J Biemond³  Rogier R Jansen² 

[1] Department of Medical Microbiology, Academical Medical Centre, University of Amsterdam, Amsterdam, the Netherlands;Academical Medical Centre, Room L1-245, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands;Department of Hematology, Academical Medical Centre, University of Amsterdam, Amsterdam, the Netherlands

关键词: Neutropenia;    PCR;    Quantitative;    Virus;    Respiratory;   

Others  :  1149367
DOI  :  10.1186/1743-422X-10-212

 received in 2012-11-20, accepted in 2013-05-23,  发布年份 2013

【 摘 要 】

Background

During febrile neutropenia in only 30 to 60 percent an infectious agent is identified. This diagnostic gap could hypothetically be reduced with the broad implementation of molecular detection techniques like PCR, which has revolutionized the detection of infectious diseases during the last two decades.

Findings

We performed a longitudinal prospective study (N = 81) of neutropenic patients to assess the role of respiratory viruses in neutropenic fever and to determine the clinical relevance of blind screening for these viruses. Respiratory viruses were recovered in 14% of the patients prior to neutropenia. In 13% of neutropenic patients without fever and in 19% of those with fever, a respiratory virus was detected. Comparing different sample types; nasal swabs performed significantly better (16/117 = 43%), than throat swabs (6/106 = 6%). Throat gurgles did not show significant differences from the latter sample types.

Conclusions

Blind diagnostic screening for respiratory viruses before or during neutropenia is not useful. Nasal swabs are sensitive and practical option for screening on respiratory viruses.

【 授权许可】

   
2013 Jansen et al.; licensee BioMed Central Ltd.

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