Perilesional edema in radiation necrosis reflects axonal degeneration

Radiation Oncology

Joel R Garbow¹  Joseph JH Ackerman¹  Keith M Rich²  Robert E Schmidt³  Liya Yuan²  Carlos J Perez-Torres⁴ 

[1] Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA;Department Neurosurgery, Washington University, Saint Louis, MO, USA;Department of Neuropathology, Washington University, Saint Louis, MO, USA;Department of Radiology, Washington University, Campus Box 8227, 4525 Scott Avenue, Saint Louis 63110, MO, USA

关键词: Axonal degeneration;    White matter injury;    Radiation necrosis;   

Others  :  1149839
DOI  :  10.1186/s13014-015-0335-6

 received in 2014-10-14, accepted in 2015-01-18,  发布年份 2015

【 摘 要 】

Background

Recently, we characterized a Gamma Knife® radiation necrosis mouse model with various magnetic resonance imaging (MRI) protocols to identify biomarkers useful in differentiation from tumors. Though the irradiation was focal to one hemisphere, a contralateral injury was observed that appeared to be localized in the white matter only. Interestingly, this injury was identifiable in T2-weighted images, apparent diffusion coefficient (ADC), and magnetization transfer ratio (MTR) maps, but not on post-contrast T1-weighted images. This observation of edema independent of vascular changes is akin to the perilesional edema seen in clinical radiation necrosis.

Findings

The pathology underlying the observed white-matter MRI changes was explored by performing immunohistochemistry for healthy axons and myelin. The presence of both healthy axons and myelin was reduced in the contralateral white-matter lesion.

Conclusions

Based on our immunohistochemical findings, the contralateral white-matter injury is most likely due to axonal degeneration.

【 授权许可】

   
2015 Perez-Torres et al.; licensee BioMed Central.

【 图 表 】

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