Three synchronous, sporadic and separate periampullary and pancreatic tumors: more than a coincidence?

World Journal of Surgical Oncology

Avram M Cooperman²  Songyang Yuan¹  Mazen Iskandar²  Justin Steele²  Michael Wayne²  Amit Sastry² 

[1] Department of Pathology, Mount Sinai Beth Israel, 1st ave at 16th St, New York, NY 10003, USA;Department of Surgery, Mount Sinai Beth Israel, 37 Union Square West, 4th floor, New York, NY 10003, USA

关键词: Adenosquamous;    Neuroendocrine tumor;    Pancreatic adenocarcinoma;    Synchronous;    Pancreas;   

Others  :  1146918
DOI  :  10.1186/1477-7819-12-382

 received in 2013-12-27, accepted in 2014-11-18,  发布年份 2014

【 摘 要 】

Three sporadic, synchronous, and separate lesions in the ampulla of Vater and the head of the pancreas presented in an 81-year-old male. One was symptomatic and two were incidental. One was detected preoperatively (the ampullary lesion) and two by examination of the resected specimen (the neuroendocrine and pancreatic carcinomas). The case is summarized and the literature and the issue of commonality are reviewed.

【 授权许可】

   
2014 Sastry et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

【 参考文献 】

• [1]Artac M, Bozcuk H, Ozdogan M, Demiral A, Sarpe A, Samur M, Sava B: Different clinical features of primary and secondary tumors in patients with multiple malignancies. Tumori 2005, 91:317-320.
• [2]Dong C, Hemminki K: Second primary neoplasms in 633,964 cancer patients in Sweden 1958-1996. Int J Cancer 2001, 93:155-161.
• [3]Van Westreenen HL, Westerterp M, Jager PL, van Dullemen HM, Sloof GW, Comans EFI, van Lanschot JJB, Wiggers T, Plukker JTM: Synchronous primary neoplasms detected on 18F-FDG PET in staging of patients with esophageal cancer. J Nucl Med 2005, 46:1321-1325.
• [4]Crocetti E, Arniani S, Buiatti E: Synchronous and metachronous diagnosis of multiple primary cancers. Tumori 1998, 84:9-13.
• [5]Mehdi I, Shah AH, Moona MS, Verma K, Abussa A, Elramih R, El-Hashmi H: Synchronous and metachronous malignant tumours expect the unexpected. J Pak Med Assoc 2010, 60:905.
• [6]Bittorf B, Kessler H, Merkel S, Brückl W, Wein A, Ballhausen WG, Hohenberger W, Günther K: Multiple primary malignancies: an epidemiological and pedigree analysis of 57 patients with at least three tumours. Euro J Surg Oncol 2001, 27:302-313.
• [7]Hemminki K, Boffetta P: Multiple primary cancers as clues to environmental and heritable causes of cancer and mechanisms of carcinogenesis. IARC Sci Publ 2004, 157:289-297.
• [8]Chinn SB, Spector ME, Prince ME: Synchronous and metachronous tumors in head and neck cancer: analysis of the SEER database. Otolaryngol - Head Neck Surg 2013, 149:198.
• [9]Kilciksiz S, Gokce T, Baloglu A, Calli A, Kaynak C, Kilic B, Eski E, Nalbantoglu G, Yititbas HA: Characteristics of synchronous- and metachronous-type multiple primary neoplasms: a study of hospital-based cancer registry in Turkey. Clin Genitourin Cancer 2007, 5:438-445.
• [10]Carey TE: Field cancerization: are multiple primary cancers monoclonal or polyclonal? Ann Med 1996, 28:183-188.
• [11]Moore PS, Zamboni G, Brighenti A: Molecular characterization of pancreatic serous microcystic adenomas: evidence for a tumor suppressor gene on chromosome 10q. Amer J Path 2001, 158:317-321.
• [12]Kadota Y, Shinoda M, Tanabe M, Tsujikawa H, Ueno A, Masugi Y, Oshima G, Nishiyama R, Tanaka M, Mihara K, Abe Y, Yagi H, Kitago M, Itano O, Kawachi S, Aiura K, Tanimoto A, Sakamaoto M, Kitagawa Y: Concomitant pancreatic endocrine neoplasm and intraductal papillary mucinous neoplasm: a case report and literature review. World J Surg Oncol 2013, 11:75. BioMed Central Full Text
• [13]Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, Chung YF, Wong WK: Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatol 2006, 6:520-526.
• [14]Terada T, Ohta T, Kitamura Y, Ashida K, Matsunaga Y, Kato M: Endocrine cells in intraductal papillary-mucinous neoplasms of the pancreas. A histochemical and immunohistochemical study. Virchows Arch 1997, 431:31-36.
• [15]Schleger C, Arens N, Zentgraf H, Bleyl U, Verbeke C: Identification of frequent chromosomal aberrations in ductal adenocarcinoma of the pancreas by comparative genomic hybridization (CGH). J Pathol 2000, 19:27-32.
• [16]Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ, Misek DE, Kuick R, Hanash S: Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 2003, 63:2649-2657.
• [17]Hashimoto Y, Murakami Y, Uemura K, Hayashidani Y, Sudo T, Ohge H, Sueda T, Shimamoto F, Hiyama E: Mixed ductal-endocrine carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas identified by human telomerase reverse transcriptase (hTERT) expression. J Surg Oncol 2008, 97:469-475.
• [18]Aydiner A, Karadeniz A, Uygun K, Tas S, Tas F, Disci R, Topuz E: Multiple primary neoplasm at a single institution: differences between synchronous and metachronous neoplasms. Am J Clin Oncol 2000, 23:364-370.
• [19]Ueno M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T: Multiple primary cancer: an experience at the Cancer Instute Hospital with special reference to colorectal cancer. Int J Clin Oncol 2003, 8:162-167.
• [20]Yamaguchi K, Kanemitsu S, Hatori T, Maguchi H, Shimizu Y, Tada M, Nakagohri T, Hanada K, Osanai M, Noda Y, Nakaizumi A, Furukawa T, Ban S, Nobukawa B, Kato Y, Tanaka M: Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. Pancreas 2011, 40:571-580.
• [21]Mori Y, Ohtsuka T, Tsutsumi K, Yasui T, Sadakari Y, Ueda J, Takahata S, Nakamura M, Tanaka M: Multifocal pancreatic ductal adenocarcinomas concomitant with intraductal papillary mucinous neoplasms of the pancreas detected by intraoperative pancreatic juice cytology. A case report. JOP 2010, 11:389-392.
• [22]Chen D, Yan J, Mou Y: Metachronous pancreatic head ductal carcinoma three years after resection of gallbladder cancer. Int J Clin Exp Med 2013, 6:828.
• [23]Agarwal N, Kumar S, Sharma S: Synchronous adenocarcinoma of the gall bladder and pancreas in a young woman. Trop Gastroenterol 2013, 34:50-52.
• [24]Albores-Saavedra J, Schwartz AM, Batich K, Henson DE: Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program. J Surg Oncol 2009, 100:598-605.
• [25]Yang SJ, Ooyang CH, Wang SY: Adenosquamous carcinoma of the ampulla of Vater-a rare disease at unusual location. World J Surg Oncol 2013, 11:124. BioMed Central Full Text
• [26]Lee DK, Park CK, Ahn GH: Adenosquamous carcinoma of the ampulla of vater a report of two cases. Korean J Pathol 2006, 40:160-164.
• [27]Wohlauer MV, McManus MC, Brauer B, Hedges J, Gajdos C: Synchronous presentation of ampullary adenocarcinoma and common bile duct cancer: report of a case and review of literature. JOP 2012, 13:536-539.
• [28]Winter JM, Cameron JL, Lillemoe KD, Campbell KA, Chang D, Riall TS, Coleman J, Sauter PK, Canto M, Hruban RH, Schulick RD, Choti MA, Yeo CJ: Periampullary and pancreatic incidentaloma: a single institution's experience with an increasingly common diagnosis. Ann Surg 2006, 243:673.
• [29]Modlin IM, Lye KD, Kidd M: A 5 decade analysis of 13,715 carcinoid tumors. Cancer 2003, 97:934-959.