Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature

World Journal of Surgical Oncology

Yuko Kitagawa¹  Minoru Tanabe¹  Michiie Sakamoto²  Akihiro Tanimoto³  Shigeyuki Kawachi¹  Minoru Kitago¹  Hiroshi Yagi¹  Yuta Abe¹  Taizo Hibi¹  Kisho Mihara¹  Akihisa Ueno³  Osamu Itano¹  Yohei Masugi²  Hanako Tsujikawa²  Yoshie Kadota¹  Masahiro Shinoda¹ 

[1] Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan;Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan;Department of Diagnostic Radiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan

关键词: Hepatocellular carcinoma;    Lymphoepithelioma-like carcinoma;    Lymphoepithelioma;   

Others  :  825525
DOI  :  10.1186/1477-7819-11-97

 received in 2012-10-28, accepted in 2013-04-08,  发布年份 2013

【 摘 要 】

We report a rare case of lymphoepithelioma-like hepatocellular carcinoma. A 79-year-old Japanese man had undergone curative resection of extrahepatic bile ducts because of bile duct cancer 9 years prior. The bile duct cancer was diagnosed as mucosal adenocarcinoma, and the patient had been followed up every 6 months for the last 9 years. A recent computed tomography examination revealed a tumor, 4.2 cm in size, in the lateral segment of the liver. Based on the imaging findings, the tumor was diagnosed as hepatocellular carcinoma. Serology tests were negative for hepatitis B and C viruses. Chest and abdominal image analyses showed no evidence of metastasis, but a swollen lymph node was noted around the abdominal aorta. The patient subsequently underwent extended lateral segmentectomy and resection of the swollen lymph node. Microscopically, the tumor had the characteristic appearance of poorly differentiated hepatocellular carcinoma. Moreover, an abundant infiltration of inflammatory cells was observed in the tumor. Therefore, we diagnosed the tumor as lymphoepithelioma-like hepatocellular carcinoma. The resected para-aortic lymph node also had a carcinoma with features similar to those of the main tumor. The patient has been alive for 20 months since performance of the surgery. Since the first report of lymphoepithelioma-like hepatocellular carcinoma in 2000, only nine cases have been reported in the medical literature, and the clinicopathological features of the disease have not been well documented. Herein, we describe the clinicopathological features of this case for further understanding of the disease and review past cases in the literature.

【 授权许可】

   
2013 Shinoda et al.; licensee BioMed Central Ltd.

【 图 表 】

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