Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines

Retrovirology

John P Moore¹  Per Johan Klasse¹ 

[1] Department of Microbiology and Immunology, Weill Cornell Medical College, Cornel University, 1300 York Avenue, Box 62, New York, NY, 10065-4896, USA

关键词: Innate immunity;    Synergy;    RV144;    Vaccine trials;    HIV;    SIV;    In vivo mechanisms;    Mucosal immunity;    Neutralizing antibodies;    Correlates of protection (CoP);   

Others  :  1209262
DOI  :  10.1186/1742-4690-9-80

 received in 2012-08-13, accepted in 2012-09-14,  发布年份 2012

【 摘 要 】

Correlates of protection (CoPs) against infection by primate lentiviruses remain undefined. Modest protection against HIV-1 was observed in one human vaccine trial, whereas previous trials and vaccine-challenge experiments in non-human primates have yielded inconsistent but intriguing results. Although high levels of neutralizing antibodies are known to protect macaques from mucosal and intravenous viral challenges, antibody or other adaptive immune responses associated with protection might also be mere markers of innate immunity or susceptibility. Specific strategies for augmenting the design of both human trials and animal experiments could help to identify mechanistic correlates of protection and clarify the influences of confounding factors. Robust protection may, however, require the combined actions of immune responses and other host factors, thereby limiting what inferences can be drawn from statistical associations. Here, we discuss how to analyze immune protection against primate lentiviruses, and how host factors could influence both the elicitation and effectiveness of vaccine-induced responses.

【 授权许可】

   
2012 Klasse and Moore; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

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