WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?

Retrovirology

Luc Willems¹  Pierre-Yves Barez¹  Alexandre Carpentier¹  Nicolas Gillet¹ 

[1] Molecular biology, GxABT, University of Liège, Gembloux, Belgium

关键词: Chk2;    ATM;    Genomic stress;    DNA damage response;    MDM2;    PPM1D;    Wip1;    p53;    HBZ;    Tax;    HTLV-1;   

Others  :  1209201
DOI  :  10.1186/1742-4690-9-115

 received in 2012-11-16, accepted in 2012-12-15,  发布年份 2012

【 摘 要 】

Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-induced phosphatase 1 (Wip1), contributes to Tax-induced oncogenesis in a mouse model. Wip1 may therefore be a novel target for therapeutic approaches.

【 授权许可】

   
2012 Gillet et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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