Human cytomegalovirus tegument proteins (pp65, pp71, pp150, pp28)

Virology Journal

John Paul Tomtishen III¹ 

[1] Bucknell University, Cell Biology/Biochemistry Program, One Dent Drive, Lewisburg, PA 17837, USA

关键词: Confocal microscopy;    Transfection;    pp28;    pp150;    pp71;    pp65;    Tegument;    HCMV;    Human cytomegalovirus;   

Others  :  1155201
DOI  :  10.1186/1743-422X-9-22

 received in 2011-11-22, accepted in 2012-01-17,  发布年份 2012

【 摘 要 】

Human cytomegalovirus (HCMV), a member of the Betaherpesvirinae sub-family of Herpesviridae family, is a widespread pathogen that infects a majority of the world's population by early adulthood. In individuals whose immune systems are immature or weakened, HCMV is a significant pathogen causing morbidity and mortality. There is no effective vaccine and only limited antiviral treatments against HCMV infection to date. A possible target for novel antiviral treatments is the HCMV proteins that localize to the tegument of the virion, since they play important roles in all stages of the viral life cycle, including, viral entry, gene expression, immune evasion, assembly, and egress. The most likely tegument protein candidates are pp65 (immune evasion), pp71 (gene expression), and pp150 and pp28 (assembly and egress). Although the subcellular localization of these proteins has been identified during HCMV infections in vitro, their localization patterns have not been determined when each protein is expressed individually in living cells. Thus, the objective of this review is elucidate the HCMV tegument as well as present current research findings concerning the subcellular localization of the tegument proteins pp65, pp71, pp150, and pp28 as fusions to one of several fluorescent proteins.

【 授权许可】

   
2012 Tomtishen III; BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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