Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients

Radiation Oncology

Keiichi Nakagawa³  Takuma Nomiya⁵  Yukinori Matsuo⁶  Naoya Murakami¹  Yasuo Matsumoto⁴  Hiroshi Onishi²  Hideomi Yamashita³ 

[1]Department of Radiation Oncology, National Cancer Center Hospital, Singapore, Singapore

[2]Department of Radiology, University of Yamanashi, Yamanashi, Japan

[3]Department of Radiology, University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

[4]Department of Radiology, Niigata Cancer Center Hospital, Niigata, Japan

[5]Department of Radiation Oncology, Yamagata University Hospital, Yamagata, Japan

[6]Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan

关键词: Stereotactic ablative radiotherapy;    Stereotactic body radiotherapy;    Metastatic liver tumor;    Hepatocellular carcinoma;   

Others  :  805185
DOI  :  10.1186/1748-717X-9-112

 received in 2014-01-20, accepted in 2014-04-21,  发布年份 2014

【 摘 要 】

Background and aims

Stereotactic body radiotherapy (SBRT) is a relatively new treatment for liver tumor. The outcomes of SBRT for liver tumor unfit for ablation and surgical resection were evaluated.

Methods

Liver tumor patients treated with SBRT in seven Japanese institutions were studied retrospectively. Patients given SBRT for liver tumor between 2004 and 2012 were collected. Patients treated with SBRT preceded by trans-arterial chemoembolization (TACE) were eligible. Seventy-nine patients with hepatocellular carcinoma (HCC) and 51 patients with metastatic liver tumor were collected. The median biologically effective dose (BED) (α/β = 10 Gy) was 96.3 Gy for patients with HCC and 105.6 Gy with metastatic liver tumor.

Results

The median follow-up time was 475.5 days in patients with HCC and 212.5 days with metastatic liver tumor. The 2-year local control rate (LCR) for HCC and metastatic liver tumor was 74.8% ± 6.3% and 64.2 ± 9.5% (p = 0.44). The LCR was not different between BED₁₀ ≥ 100 Gy and < 100 Gy (p = 0.61). The LCR was significantly different between maximum tumor diameter > 30 mm vs. ≤ 30 mm (64% vs. 85%, p = 0.040) in all 130 patients. No grade 3 laboratory toxicities in the acute, sub-acute and chronic phases were observed.

Conclusions

There was no difference in local control after SBRT in the range of median BED₁₀ around 100 Gy for between HCC and metastatic liver tumor. SBRT is safe and might be an alternative method to resection and ablation.

Summary

There was no difference in local control after SBRT in the range of median BED₁₀ around 100 Gy for between HCC and metastatic liver tumor and SBRT is safe and might be an alternative method to resection and ablation.

【 授权许可】

   
2014 Yamashita et al.; licensee BioMed Central Ltd.

【 图 表 】

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