Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients

Respiratory Research

Nanshan Zhong⁵  Michael D Spangfort⁹  Jing Zhao¹  Changqing Zhao⁶  Jinzhun Wu⁴  Guolin Tan²  Deyu Zhao⁸  Xiaoping Lin⁷  Ying Huang³  Jing Li⁵ 

[1] Capital Institute of Pediatrics, Beijing, China;The Third Hospital of Xiangya Medical University, Changsha, Hunan, China;The Children's Hospital, Chongqing University of Medical Sciences, Chongqing, China;The First Hospital of Xiamen, Xiamen, Fujian, China;State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China;The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China;The General Hospital of Shenyang Military Command, Shenyang, Liaoning, China;Nanjing Children's Hospital, Nanjing, Jiangsu, China;ALK-Abello A/S, Asia Pacific Region, Hongkong, China

关键词: association.;    asthma;    allergic rhinitis;    disease severity;    aeroallergens;    sensitization;   

Others  :  796827
DOI  :  10.1186/1465-9921-12-95

 received in 2011-03-28, accepted in 2011-07-15,  发布年份 2011

【 摘 要 】

Background

The association between sensitizations and severity of allergic diseases is controversial.

Objective

This study was to investigate the association between severity of asthma and rhinitis and degree of specific allergic sensitization in allergic patients in China.

Method

A cross-sectional survey was performed in 6304 patients with asthma and/or rhinitis from 4 regions of China. Patients completed a standardized questionnaire documenting their respiratory and allergic symptoms, their impact on sleep, daily activities, school and work. They also underwent skin prick tests with 13 common aeroallergens. Among the recruited subjects, 2268 provided blood samples for serum measurement of specific IgE (sIgE) against 16 common aeroallergens.

Results

Significantly higher percentage of patients with moderate-severe intermittent rhinitis were sensitized to outdoor allergens while percentage of patients sensitized to indoor allergens was increased with increasing severity of asthma. Moderate-severe intermittent rhinitis was associated with the skin wheal size and the level of sIgE to Artemisia vulgaris and Ambrosia artemisifolia (p < 0.001). Moderate-severe asthma was associated with increasing wheal size and sIgE response to Dermatophagoides (D.) pteronyssinus and D. farinae (p < 0.001). Moderate-severe rhinitis and asthma were also associated with increase in number of positive skin prick test and sIgE.

Conclusions

Artemisia vulgaris and Ambrosia artemisifolia sensitizations are associated with the severity of intermittent rhinitis and D. pteronyssinus and D. farinae sensitizations are associated with increasing severity of asthma in China. Increase in number of allergens the patients are sensitized to may also increase the severity of rhinitis and asthma.

【 授权许可】

   
2011 Li et al; licensee BioMed Central Ltd.

【 图 表 】

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