Comparison of capecitabine and 5-fluorouracil in chemoradiotherapy for locally advanced pancreatic cancer

Radiation Oncology

Joong-Won Park¹  Dae Yong Kim¹  Joo-Young Kim¹  Sang-Jae Park¹  Young Hwan Koh¹  Sang Soo Kim¹  Sung Ho Moon¹  Bo Hyun Kim¹  Sung-Sik Han¹  Tae Hyun Kim¹  Sang Myung Woo¹  Woo Jin Lee¹  Yeon-Joo Kim¹ 

[1] Center for Liver Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea

关键词: Capecitabine;    5-Fluorouracil;    Chemoradiotherapy;    Pancreatic cancer;   

Others  :  1153615
DOI  :  10.1186/1748-717X-8-160

 received in 2013-03-28, accepted in 2013-06-28,  发布年份 2013

【 摘 要 】

Background

Although capecitabine has theoretical advantages in the pharmacokinetics, such as higher intratumoral and lower systemic concentration, relative to bolus 5-fluorouracil (5-FU), outcomes of chemoradiotherapy (CRT) with capecitabine or bolus 5-FU have not been directly compared in patients with locally advanced pancreatic cancer. Therefore, we retrospectively compared the outcomes, including toxicity, tumor response, and overall survival, of oral capecitabine plus radiotherapy (RT) with bolus 5-FU plus RT, in patients with locally advanced pancreatic cancer.

Methods

Between August 2006 and January 2012, 98 patients with locally advanced pancreatic cancer received CRT, with 52 receiving concurrent oral capecitabine and 46 receiving bolus injection of 5-FU. Primary tumor and overall response after CRT were evaluated radiologically, and toxicity, tumor response, and overall survival (OS) were compared in the two groups.

Results

Baseline clinical parameters of the two groups were similar. The rates of ≥ Grade 3 hematologic (0% vs. 8.7%, p = 0.045) and non-hematologic (0% vs. 8.7%, p = 0.045) toxicities were significantly lower in the capecitabine group than in the 5-FU group. Primary tumor (30.7% vs. 28.2%, p = 0.658) and overall (13.7% vs. 15.2%, p = 0.273) response rates and median OS time (12.5 months vs. 11.6 months, p = 0.655) were similar in the two groups.

Conclusions

Capecitabine plus RT may be a safe and feasible regimen for patients with locally advanced pancreatic cancer, with similar efficacy and low rates of toxicities compared with bolus 5-FU plus RT.

【 授权许可】

   
2013 Kim et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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