A dosimetric comparison of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and paranasal sinus cancer

Radiation Oncology

Seung Do Ahn¹  Ji Hyeon Joo¹  Su Ssan Kim¹  Young Seok Kim¹  Si Yeol Song¹  Eun Kyung Choi¹  Jin-hong Park¹  Jong Hoon Kim¹  Sang Min Yoon¹  Ilsung Cho¹  Jungwon Kwak¹  Sang-wook Lee¹  Yuri Jeong¹ 

[1] Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro-43-gil, Songpa-gu, Seoul 138-736, Republic of Korea

关键词: Organs at risk;    Planning target volume;    Non-coplanar intensity modulated radiotherapy;    Volumetric modulated arc therapy;    Nasal cavity cancer;    Paranasal sinus cancer;   

Others  :  1151589
DOI  :  10.1186/1748-717X-9-193

 received in 2014-03-26, accepted in 2014-08-09,  发布年份 2014

【 摘 要 】

Background

To compare dosimetric parameters of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and paranasal sinus cancer with regard to the coverage of planning target volume (PTV) and the sparing of organs at risk (OAR).

Methods

Ten patients with nasal cavity or paranasal sinus cancer were re-planned by VMAT (two-arc) plan and non-coplanar IMRT (7-, 11-, and 15-beam) plans. Planning objectives were to deliver 60 Gy in 30 fractions to 95% of PTV, with maximum doses (D_max) of <50 Gy to the optic nerves, optic chiasm, and brainstem, <40 Gy to the eyes and <10 Gy to the lenses. The target mean dose (D_mean) to the parotid glands was <25 Gy, and no constraints were applied to the lacrimal glands. Planning was optimized to minimized doses to OAR without compromising coverage of the PTV. VMAT and three non-coplanar IMRT (7-, 11-, and 15-beam) plans were compared using the heterogeneity and conformity indices (HI and CI) of the PTV, D_max and D_mean of the OAR, treatment delivery time, and monitor units (MUs).

Results

The HI and CI of VMAT plan were superior to those of the 7-, 11-, and 15-beam non-coplanar IMRT. VMAT and non-coplanar IMRT (7-, 11-, and 15-beam) showed equivalent sparing effects for the optic nerves, optic chiasm, brainstem, and parotid glands. For the eyes and lenses, VMAT achieved equivalent or better sparing effects when compared with the non-coplanar IMRT plans. VMAT showed lower MUs and reduced treatment delivery time when compared with non-coplanar IMRT.

Conclusions

In 10 patients with nasal cavity or paranasal sinus cancer, a VMAT plan provided better homogeneity and conformity for PTV than non-coplanar IMRT plans, with a shorter treatment delivery time, while achieving equal or better OAR-sparing effects and using fewer MUs.

【 授权许可】

   
2014 Jeong et al.; licensee BioMed Central Ltd.

【 图 表 】

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