Hepatoid adenocarcinoma of the gallbladder

World Journal of Surgical Oncology

Boudawara Tahia²  Ben Amar Mohamed³  Kossentini Mariem²  Mnif Héla²  Amouri Ali¹  Gouiaa Naourez²  Guirat Ahmad³  Charfi Slim²  Sameh Ellouze² 

[1] Department of gastroenterology, Hedi Chaker hospital, road El Ain., 3029 Sfax, Tunisia;Department of pathology, Habib Bourguiba Hospital, road El Ain., 3029, Sfax, Tunisia;Department of surgery, Habib Bourguiba hospital, road El Ain., 3029, Sfax, Tunisia

关键词: hepathocellular carcinoma;    liver;    histopathology;    gallbladder;    adenocarcinoma;    Hepatoid;   

Others  :  1206661
DOI  :  10.1186/1477-7819-9-103

 received in 2011-01-30, accepted in 2011-09-13,  发布年份 2011

【 摘 要 】

Hepatoid adenocarcinoma is a rare variant of extrahepatic adenocarcinoma which behaves like hepatocellular carcinoma in morphology and functionality.

We present a rare case of hepatoid adenocarcinoma of the gallbladder which invades deeply the liver bed, in a 59-year-old woman. Histologically, most of the mass in the gallbladder was composed of cells with eosinophilic cytoplasm arranged in a trabecular pattern, which resembled hepatocellular carcinoma. The main differential diagnosis was hepatocellular carcinoma with invasion into the gallbladder. The gallbladder origin of the hepatoid adenocarcinoma was verified by the presence of foci of conventional adenocarcinoma, the recognition of high-grade dysplasia in the adjacent epithelium and the absence of cirrhosis.

【 授权许可】

   
2011 Sameh et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

【 参考文献 】

• [1]Sakamoto K, Monobe Y, Kouno M, Moriya1 T, Sasano H: Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature. Pathology International 2004, 54:52-56.
• [2]Gakiopoulou H, Givalos N, Liapis G, Agrogiannis G, Patsouris E, Delladetsima I: Hepatoid Adenocarcinoma of the Gallbladder. Dig Dis Sci 2007, 52:3358-3362.
• [3]Vardaman C, Albores-Saavedra J: Clear cell carcinomas of the gallbladder and extrahepatic bile ducts. Am J Surg Pathol 1995, 19:91-99.
• [4]Nakashima H, Nagafuchi K, Satoh H, et al.: Hepatoid adenocarcinoma of the gallbladder. J Hepatobiliary Pancreat Surg 2000, 7:226-230.
• [5]Van Den Bos IC, Hussain SM, Dwarkasing RS, et al.: Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma. The British Journal of Radiology 2007, 80:e317-e320.
• [6]Sakamoto K, Kimura N, Tokumura H, Ogasawara T, Moriya T, Sasano H: Hepatoid adenocarcinoma of the gallbladder. Histopathology 2005, 47:643-652.