Platelet function in the postprandial period

Thrombosis Journal

Robert Berent¹  Helmut Sinzinger² 

[1] Center for Cardiovascular Rehabilitation, Rehabilitationszentrum Austria, Bad Schallerbach, Austria;Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria

关键词: Atherosclerosis;    Platelet count;    Platelet aggregation;    Platelet activity;    Postprandial hyperlipidemia;   

Others  :  838843
DOI  :  10.1186/1477-9560-10-19

 received in 2012-02-13, accepted in 2012-08-27,  发布年份 2012

【 摘 要 】

Background

Postprandial hyperlipidemia and hyperglycemia have been related to cardiovascular events. Among different underlying mechanisms platelet activation seems to be responsible too. No comparable data between various tests in normo- vs. hyperlipidemics before and at different time intervals are available after a fat meal. We aimed to compare 9 of them within the same patients at several time points in postprandial hyperlipidemia.

Results

For some tests baseline values between the groups were significantly different (TXB₂, platelet sensitivity, sedimentation and WU-test). However, hyperlipidemia revealed a variable influence on the tests examined. Some of the available tests apparently sensitive to show platelet activation reflect the increase in triglycerides (TG), such as the sedimentation index. ADP-induced platelet aggregatory activity in count adjusted washed isolated platelet samples during postprandial hyperlipidemia indicates mildly enhanced platelet activity, but does not seem to induce significant changes in aggregation. In patients with severe hypertriglyceridemia (> 400 mg/dl fasting) changes in platelet function are more pronounced due to delayed decay and may last up to 16 hours paralleling TG reaching the prevalue. The overwhelming majority of platelet function tests do not significantly respond to postprandial hyperlipidemia. The correlation between the tests applied is poor. For standardization purpose, platelet aggregation tests, aimed to examine proaggregatory capacity in atherosclerosis, should only be performed at the same time of the day after a fasting period > 6 hours. The great variation in preanalytical work-up on comparison of various tests, large number of platelet tests available and their respective potential value are discussed.

Conclusions

At present, the suspicion that platelet function is significantly activated in the postprandial period cannot be supported by any of the tests used. The information provided is valuable to know for which test and group of patients a fasting period of which duration is recommendable.

【 授权许可】

   
2012 Sinzinger and Berent; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Patsch JR, Miesenböck G, Hopferwieser T, Mühlberger V, Knapp E, Dunn JK, Gotto AM Jr, Patsch W: Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler Thromb 1992, 12:1336-1345.
• [2]Karpe F, Steiner G, Uffelman K, Olivecrona T, Hamsten A: Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis 1994, 106:83-97.
• [3]Berlinerblau R, Shani J: Postprandial angina pectoris: clinical and angiographic correlations. J Am Coll Cardiol 1994, 23:627-629.
• [4]Duttaroy AK: Postprandial activation of hemostatic factors: Role of dietary fatty acids. Prostagl Leukot Essent Fatty Acids 2005, 72:381-391.
• [5]Hyson DA, Paglieroni TG, Wun T, Rutledge JC: Postprandial lipemia is associated with platelet and monocyte activation and increased monocyte cytokine expression in normolipemic men. Clin Appl Thromb Hemost 2002, 8:147-155.
• [6]Shastri KM, Carvalho ACA, Lees RS: Platelet function and platelet lipid composition in the dyslipoproteinemias. J Lipid Res 1980, 21:467.
• [7]Belch JJF, Sanibaldi AR, McLaughlin K, Forbes CD: Platelet changes after a saturated fat meal and their preventions by Dazmegrel, a thromboxane synthetase inhibitor. Lipids 1987, 22:159-162.
• [8]Nordoy A, Strom E, Gjesdal K: The effect of alimentary hyperlipaemia and primary hypertriglyceridaemia on platelets in man. Scand J Haematol 1974, 12:329-340.
• [9]Nordoy A, Lagarde M, Renaud S: Platelets during alimentary hyperlipaemia induced by cream and cod liver oil. Eur J Clin Invest 1984, 14:339-345.
• [10]Bröijersén A, Karpe F, Hamsten A, Goodall AH, Hjemdahl P: Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation. Atherosclerosis 1998, 137:107-113.
• [11]Michelsen AE, Noto AT, Brodin E, Mathiesen EB, Brosstad F, Hansen JB: Elevated levels of platelet microparticles in carotid atherosclerosis and during the postprandial state. Thromb Res 2009, 123:881-886.
• [12]Freese R, Mutanen M: Postprandial changes in platelet function and coagulation factors after high-fat meals with different fatty acid compositions. Eur J Clin Nutr 1995, 49:658-664.
• [13]Aviram M, Fuhrman B, Brook JG: Postprandial plasma lipoproteins in normal and hypertriglyceridaemic subjects and there in vitro effect on platelet activity: differences between saturated and polyunsaturated fats. Scand J Clin Lab Invest 1986, 46:571-579.
• [14]Aviram M, Rosenblat M, Potesman M, Dankner G, Brook JG: Plasma lipoprotein and platelet function after heparin injection: studies in normal fasted and postprandial and in type V hyperlipoproteinemic subjects. Biochem Med Metab Biol 1986, 35:279-292.
• [15]Fuhrman B, Brook JG, Aviram M: Increased platelet aggregation during alimentary hyperlipemia in normal and hypertriglyceridemic subjects. Ann Nutr Metab 1986, 30:250-260.
• [16]Nimpf J, Malle E, Leopold B, Wurm H, Kostner GM: Postprandial hyperlipemia inhibits platelet aggregation without affecting prostanoid metabolism. Prostagl Leukotr Essent Fatty Acids 1989, 37:7-13.
• [17]Malle E, Nimpf J, Leis HJ, Wurm H, Kostner GM: Postprandial hyperlipemia and platelet eicosanoid metabolism. Klin Wochenschr 1990, 68:116.
• [18]Ahuja KD, Adams MJ, Robertson IK, Ball MJ: Acute effect of a high-carbohydrate low-fat meal on platelet aggregation. Platelets 2009, 20:606-609.
• [19]Bisovsky S, Richter H, Fitscha P, O’Grady J, Sinzinger H: Postprandial hyperlipemia does not inhibit platelet aggregation. Prostagl Leukotr Essent Fatty Acids 1992, 47:331-332.
• [20]Sinzinger H, Pirich C, Fitscha P, O’Grady J: Enhanced in-vitro platelet aggregability during postprandial hyperlipidaemia. Lancet 1993, 341:48.
• [21]Numminen H, Kobayashi M, Uchiyama S, Iwata M, Ikeda Y, Riutta A, Syrjälä M, Kekomäki R, Hillbom M: Effects of alcohol and the evening meal on shear-induced platelet aggregation and urinary excretion of prostanoids. Alcohol Alcohol 2000, 35:594-600.
• [22]Randriamboavonjy V, Fleming I: Insulin, insulin resistance and platelet signaling in diabetes. Diabetes Care 2009, 32:528-530.
• [23]Hiramatsu K, Nozaki H, Arimori S: Reduction of platelet aggregation induced by euglycaemic insulin clamp. Diabetologia 1987, 30:310-313.
• [24]Westerbacka J, Yki-Jarvinen H, Turpeinen A, Rissanen A, Vehkavaara S, Syrjala M, Lassila R: Inhibition of platelet-collagen interaction: An in-vivo action of insulin abolished by insulin resistance in obesity. Thromb Vasc Biol 2002, 22:167-172.
• [25]Wiens L, Lutze G, Luley C, Westphal S: Platelet count and platelet activation: impact of a fat meal and day time. Platelets 2007, 18:171-173.
• [26]Karepov V, Tolpina G, Kuliczkowski W, Serebruany V: Plasma triglycerides as predictors of platelet responsiveness to aspirin in patients after first ischemic stroke. Cerebrovasc Dis 2008, 26:272-276.
• [27]Hodgson JM, Puddey IB, Burke V, Beilin LJ, Mori TA, Chan SY: Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects. Brit J Nutr 2002, 87:141-145.
• [28]Delgado-Lista J, Lopez-Miranda J, Cortés B, Perez-Martinez P, Lozano A, Gomez-Luna R, Gomez P, Gomez MJ, Criado J, Fuentes F, Perez-Jimenez F: Chronic dietary fat intake modifies the postprandial response of hemostatic markers to a single fatty test meal. Am J Clin Nutr 2008, 87:317-322.
• [29]Perona JS, Martinez-González J, Sanchez-Dominguez JM, Badimon L, Ruiz-Gutierrez V: The unsaponifiable fraction of virgin olive oil in chylomicrons from men improves the balance between vasoprotective and prothrombotic factors released by endothelial cells. J Nutr 2004, 134:3284-3289.
• [30]Kälsch T, Elmas E, Nguyen XD, Kralev S, Leweling H, Klüter H, Dempfle CE, Borggrefe M: Effects of alimentary lipemia and inflammation on platelet CD40-ligand. Thromb Res 2007, 120:703-708.
• [31]Shen T, Liu BW, Liu Y, Bai H, Zhang ZH: Effects of hypertriglyceridemia on platelet activities in endogenous hypertriglyceridemic patients. Sichuan Da Xue Xue Bao Yi Xue Ban 2004, 35:15-17.
• [32]Undar L, Akkoc N, Alakavuklar MN, Cehreli C, Undar L: Flow cytometric analysis of circadian changes in platelet activation using anit-GMP-140 monoclonal antibody. Chronobiol Int 1999, 16:335-342.
• [33]Unek IT, Bayraktar F, Solmaz D, Ellidokuz H, Yuksel F, Sisman AR, Yesil S: Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome. Metabolism 2010, 59:305-313.
• [34]Olufadi R, Byrne CD: Effects of VLDL and remnant particles on platelets. Pathophysiol Haemost Thromb 2006, 35:281-291.
• [35]Anderson RA, Ellis GR, Evans LM, Morris K, Chirkov YY, Horowitz JD, Jackson SK, Rees A, Lewis MJ, Frenneaux MP: Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes. Diab Vasc Dis Res 2005, 2:88-93.
• [36]Yngen M, Ostenson CG, Hjemdahl P, Wallén NH: Meal-induced platelet activation in type 2 diabetes mellitus: effects of treatment with repaglinide and glibenclamide. Diabet Med 2006, 23:134-140.
• [37]Bai H, Liu BW, Deng Z, Shen T, Fang DZ, Zhao YH, Liu Y: Plasma very-low-density lipoprotein, low-density lipoprotein, and high-density lipoprotein oxidative modification induces procoagulant profiles in endogenous hypertriglyceridemia. Free Radic Biol Med 2006, 40:1796-1803.
• [38]Gawlowski T, Stratmann B, Ruetter R, Buenting CE, Menart B, Weiss J, Vlassara H, Koschinsky T, Tschoepe D: Advanced glycation end products strongly activate platelets. Eur J Nutr 2009, 48:475-481.
• [39]Vignini A, Nanetti L, Moroni C, Testa R, Sirolla C, Marra M, Cenerelli S, Gregori A, Fumelli D, Olivieri F, Mazzanti L, Rabini RA: Platelet nitric oxide production and IR: relation with obesity and hypertriglyceridemia. Nutr Metab Cardiovasc Dis 2008, 18:553-558.
• [40]Ferretti G, Rabini RA, Bacchetti T, Vignini A, Salvolini E, Ravaglia F, Curatola G, Mazzanti L: Glycated low-density lipoproteins modify platelet properties: a compositional and functional study. J Clin Endocrinol Metab 2002, 87:2180-2184.
• [41]Brites FD, Verona J, Schreier LE, Fruchart JC, Castro GR, Wikinski RL: Paraoxonase 1 and platelet-activating factor acetylhydrolase activities in patients with low HDL-cholesterol levels with or without primary hypertriglyceridemia. Arch Med Res 2004, 35:235-240.
• [42]DiChiara J, Bliden KP, Tantry US, Hamed MS, Antonino MJ, Suarez TA, Bailon O, Singla A, Gurbel PA: The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the Aspirin-Induced Platelet Effect (ASPECT) study. Diabetes 2007, 56:3014-3019.
• [43]Calkin AC, Drew BG, Ono A, Duffy SJ, Gordon MV, Schoenwaelder SM, Sviridiv D, Cooper ME, Kingwell BA, Jackson SP: Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation 2009, 120:2095-2104.
• [44]Stalenhoef AFH, de Graaf J: Association of fasting and nonfasting serum triglycerides with cardiovascular disease and the role of remnant-like lipoproteins and small dense LDL. Curr Opin Lipidol 2008, 19:355-361.
• [45]De Man FH, Nieuwland R, van der Laarse A, Romijn F, Smelt AH, Gevers Leuven JA, Sturk A: Activated platelets in patients with severe hypertriglyceridemia: effects of triglyceride-lowering therapy. Atherosclerosis 2000, 152:407-414.
• [46]Pedreño J, Hurt-Camejo E, Wiklund O, Badimón L, Masana L: Platelet function in patients with familial hypertriglyceridemia: evidence that platelet reactivity is modulated by Apolipoproteine E content of very low-density lipoprotein particles. Metabolism 2000, 49:942-949.
• [47]Koga H, Sugiyama S, Kugiyama K, Fukushima H, Watanabe K, Sakamoto T, Yoshimura M, Jinnouchi H, Ogawa H: Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease. Eur Heart J 2006, 27:817-823.
• [48]Kolovou GD, Mikhailidis DP, Nordestgaard BG, Bilianou H, Panatopoulos G: Definition of postprandial lipaemia. Curr Vasc Pharmacol 2011, 9:292-301.
• [49]Nordestgaard BG, Freiberg JJ: Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol. Curr Vasc Pharmacol 2011, 9:281-286.
• [50]Aznar J, Santos MT, Vallés J: Effect of postprandial lipaemia on platelet function in man evaluated in whole blood. Thromb Res 1987, 48:567-576.
• [51]Brezinski DA, Tofler GH, Müller JE, Pohjola-Sintonen S, Willich SN, Schafer AI, Czeisler CA, Williams GH: Morning increase in platelet aggregability. Association with assumption of the upright posture. Circulation 1988, 78:35-40.
• [52]Jafri SM, VanRollins M, Ozawa T, Mammen EF, Goldberg AD, Goldstein S: Circadian variation in platelet function in healthy volunteers. Am J Cardiol 1992, 69:951-954.
• [53]May JA, Fox S, Glenn J, Craxford S, Heptinstall S: Platelet function reduces significantly during the morning. Platelets 2008, 19:556-558.
• [54]Boberg M, Vessby B, Croon LB: Fatty acid composition of platelets and of plasma lipid esters in relation to platelet function in patients with ischaemic heart disease. Atherosclerosis 1985, 58:49-63.
• [55]García-Guerra R, Mateo CR, García-Munoz MS, Zapata MA, Plaza I, González-Rodríguez J: Distinct cholesterol and phospholipid incorporation at the platelet plasma membrane of hyperlipidemic subjects: structural order and function. Platelets 1998, 9:365-373.
• [56]Sinzinger H, Flores J, Widhalm K, Granegger S: Platelet viability (aggregation, migration, recovery) after radiolabelling from hypercholesterolemics using various tracers (oxine, oxine-sulphate, tropolone, MPO). Eur J Nucl Med 1988, 14:358-361.
• [57]Lopez-Miranda J, Delgado-Lista J, Perez-Martinez P, Jimenez-Gómez Y, Fuentes F, Ruano J, Marin C: Olive oil and the haemostatic system. Mol Nutr Food Res 2007, 51:1249-1259.
• [58]Smith RD, Kelly CN, Fielding BA, Hauton D, Silva KD, Nydahl MC, Miller GJ, Williams CM: Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. Brit J Nutr 2003, 90:597-606.
• [59]Virgolini I, Koller E, Li S, Yang Q, Banyai M, Rauscha F, Pidlich J, Pirker W, Sinzinger H: Etofibrate increases binding of low and high density lipoprotein to human platelets of patients with type II hyperlipoproteinemia. Atherosclerosis 1993, 102:217-226.
• [60]Virgolini I, Li S, Qiong Y, Koller E, Banyai M, Angelberger P, Sinzinger H: Binding of 111In-labeled LDL to platelets of normolipemic volunteers and patients with heterozygous familial hypercholesterolemia. Arterioscl Thromb 1993, 13:536-547.
• [61]Virgolini I, Li S, Yang Q, Banyai M, Koller E, Angelberger P, Sinzinger H: Binding of 111In-labeled HDL to platelets from normolipemic volunteers and patients with heterozygous familial hypercholesterolemia. Arterioscler Thromb 1992, 12:849-961.
• [62]Santilli F, Formoso G, Sbraccia P, Averna M, Miccoli R, Di Fulvio P, Ganci A, Pulizzi N, Lattanzio S, Ciabattoni G, Consoli A, Lauro R, Patrono C, Davi G: Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus. J Thromb Haemost 2010, 8:828-837.
• [63]Assert R, Scherk G, Bumbure A, Pirags V, Schatz H, Pfeiffer AF: Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro. Diabetologia 2001, 44:188-195.
• [64]Saleh JW, Hashim SA: Altered sedimentation behaviour and ultrastructure of platelets in hyperlipidemia. Circulation 1974, 50:880.
• [65]Silberbauer KF, Sinzinger H, Haselberger K, Barcsak T, Willvonseder R: Zum physikalischen und funktionellen Verhalten der Thrombozyten bei primären und sekundären Hyperlipoproteinämien. Vasa 1977, 6:148-153.
• [66]Kolovou GD, Mikhailidis DP, Kovar J, Lairon D, Nordestgaard BG, Ooi TC, Perez-Martinez P, Bilianou H, Anagnostopoulou K, Panotopoulos G: Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol 2011, 9:258-270.