Family history of hepatocellulcar carcinoma is not associated with its patients’ prognosis after hepatectomy

World Journal of Surgical Oncology

Minshan Chen²  Li Xu²  Junting Huang²  Meixian Chen²  Yaojun Zhang²  Jia Huang¹ 

[1] Department of Obstetrics and Gynaecology, First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road Second, Guangzhou 510089, China;State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

关键词: Prognosis;    Family history;    TNM staging system;    Hepatectomy;    Hepatocellular carcinoma;   

Others  :  821098
DOI  :  10.1186/1477-7819-11-280

 received in 2013-07-25, accepted in 2013-09-30,  发布年份 2013

【 摘 要 】

Background

Family history of liver cancer is a major risk factor for hepatocellular carcinoma (HCC). In this study, we investigated the prognosis of patients with HCC with or without family history.

Methods

Data for 1,313 patients who underwent hepatectomy as initial treatment for HCC between 2000 and 2008 at a tertiary cancer center hospital were retrieved from a prospective database. A positive family history was defined as a self-reported history of HCC in first-degree relatives. Clinicopathologic characteristics were compared by family history. Kaplan-Meier method and Cox proportional hazards regressions were applied for overall survival (OS) and disease-free survival (DFS).

Results

Of 1,313 patients, 169 patients (12.9%) had first-degree relatives with a history of HCC. There were no significant differences between patients with or without family history in basic clinicopathologic characteristics. In either whole group or each stage according to the TNM staging system, first-degree family history was not associated with survival in all patients, hepatitis B virus-positive patients, as well as male patients. Multivariate analysis revealed that first-degree family history was not a prognostic factor, either for OS or DFS.

Conclusion

A first-degree family history of HCC is not associated with its patients’ prognosis after hepatectomy.

【 授权许可】

   
2013 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 4.

Figure 2.

Figure 3.

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