Circulating survivin levels in healthy and asthmatic pregnancy

Reproductive Biology and Endocrinology

Lilla Tamasi²  Ildiko Horvath²  Janos Rigo¹  Gyorgy Losonczy²  Aniko Bohacs²  Noemi Eszes²  Renata Bocskei²  Andras Bikov² 

[1] First Department of Obstetrics and Gynecology, Semmelweis University, 27 Baross utca, Budapest H-1085, Hungary;Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest H-1125, Hungary

关键词: Survivin;    Pregnancy;    Asthma;    Apoptosis;   

Others  :  1139766
DOI  :  10.1186/1477-7827-12-93

 received in 2014-05-27, accepted in 2014-09-18,  发布年份 2014

【 摘 要 】

Background

Asthma is one of the most common conditions which complicate pregnancy. Pro- and anti-apoptotic mechanisms can be modulated by asthma accompanying pregnancy. Survivin, an anti-apoptotic protein has been implicated in the pathomechanism of asthma and also in the development of pathological pregnancies; however survivin has not been studied in pregnant asthmatics.

Methods

Twenty-eight asthmatic pregnant (AP), 25 asthmatic non-pregnant (ANP), 21 healthy pregnant (HP) and 29 healthy non-pregnant (HNP) women were enrolled in this cross-sectional study. Plasma survivin concentration was determined by ELISA.

Results

Plasma survivin was significantly lower in HP (1.64 /0-74.9/ pg/ml) than in HNP (24.6 /0-333.3/ pg/ml, p = 0.01). However, this difference was not observed between the asthmatic groups (p = 0.64). Similarly, there was no difference either between HNP and ANP (10.5 /0-215.4/ pg/ml, p = 0.23) or between HP and AP (13.9 /0-364.1/ pg/ml, p = 0.30) groups.

Conclusions

Decreased plasma survivin levels in physiological but not in asthmatic pregnancy may suggest that the normal apoptotic mechanisms are compromised in asthmatic gestation.

【 授权许可】

   
2014 Bikov et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Tamasi L, Somoskovi A, Muller V, Bartfai Z, Acs N, Puho E, Czeizel AE: A population-based case–control study on the effect of bronchial asthma during pregnancy for congenital abnormalities of the offspring. J Asthma 2006, 43:81-86.
• [2]Dombrowski MP: Asthma and pregnancy. Obstet Gynecol 2006, 108:667-681.
• [3]Maselli DJ, Adams SG, Peters JI, Levine SM: Management of asthma during pregnancy. Ther Adv Respir Dis 2013, 7:87-100.
• [4]Frangsmyr L, Baranov V, Nagaeva O, Stendahl U, Kjellberg L, Mincheva-Nilsson L: Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular level. Mol Hum Reprod 2005, 11:35-41.
• [5]Taylor DD, Sullivan SA, Eblen AC, Gercel-Taylor C: Modulation of T-cell CD3-zeta chain expression during normal pregnancy. J Reprod Immunol 2002, 54:15-31.
• [6]Redman CW, Sargent IL: Circulating microparticles in normal pregnancy and pre-eclampsia. Placenta 2008, 29(A):S73-S77.
• [7]Bohacs A, Pallinger E, Tamasi L, Rigo J Jr, Komlosi Z, Muller V, Dong Y, Magyar P, Falus A, Losonczy G: Surface markers of lymphocyte activation in pregnant asthmatics. Inflamm Res 2010, 59:63-70.
• [8]Tamasi L, Bohacs A, Tamasi V, Stenczer B, Prohaszka Z, Rigo J Jr, Losonczy G, Molvarec A: Increased circulating heat shock protein 70 levels in pregnant asthmatics. Cell Stress Chaperones 2010, 15:295-300.
• [9]Cheung CH, Huang CC, Tsai FY, Lee JY, Cheng SM, Chang YC, Huang YC, Chen SH, Chang JY: Survivin - biology and potential as a therapeutic target in oncology. Onco Targets Ther 2013, 6:1453-1462.
• [10]Shiozaki A, Kataoka K, Fujimura M, Yuki H, Sakai M, Saito S: Survivin inhibits apoptosis in cytotrophoblasts. Placenta 2003, 24:65-76.
• [11]Muschol-Steinmetz C, Friemel A, Kreis NN, Reinhard J, Yuan J, Louwen F: Function of survivin in trophoblastic cells of the placenta. PLoS One 2013, 8:e73337.
• [12]Adida C, Berrebi D, Peuchmaur M, Reyes-Mugica M, Altieri DC: Anti-apoptosis gene, survivin, and prognosis of neuroblastoma. Lancet 1998, 351:882-883.
• [13]Zimmerman M, Yang D, Hu X, Liu F, Singh N, Browning D, Ganapathy V, Chandler P, Choubey D, Abrams SI, Liu K: IFN-gamma upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells. PLoS One 2010, 5:e14076.
• [14]Lehner R, Bobak J, Kim NW, Shroyer AL, Shroyer KR: Localization of telomerase hTERT protein and survivin in placenta: relation to placental development and hydatidiform mole. Obstet Gynecol 2001, 97:965-970.
• [15]Li CF, Gou WL, Li XL, Wang SL, Yang T, Chen Q: Reduced expression of survivin, the inhibitor of apoptosis protein correlates with severity of preeclampsia. Placenta 2012, 33:47-51.
• [16]Jutzy JM, Khan S, Asuncion-Valenzuela MM, Milford TA, Payne KJ, Wall NR: Tumor-released survivin induces a type-2 t cell response and decreases cytotoxic T cell function, in vitro. Cancer Microenviron 2013, 6:57-68.
• [17]Ungvari I, Hullam G, Antal P, Kiszel PS, Gezsi A, Hadadi E, Virag V, Hajos G, Millinghoffer A, Nagy A, Kiss A, Semsei AF, Temesi G, Melegh B, Kisfali P, Szell M, Bikov A, Galffy G, Tamasi L, Falus A, Szalai C: Evaluation of a partial genome screening of two asthma susceptibility regions using bayesian network based bayesian multilevel analysis of relevance. PLoS One 2012, 7:e33573.
• [18]Tumes DJ, Connolly A, Dent LA: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. Int Immunol 2009, 21:633-644.
• [19]Ungvari I, Hadadi E, Virag V, Bikov A, Nagy A, Semsei AF, Galffy G, Tamasi L, Horvath I, Szalai C: Implication of BIRC5 in asthma pathogenesis. Int Immunol 2012, 24:293-301.
• [20]Sugahara K, Uemura A, Harasawa H, Nagai H, Hirakata Y, Tomonaga M, Murata K, Sohda H, Nakagoe T, Shibasaki S, Yamada Y, Kamihira S: Clinical relevance of survivin as a biomarker in neoplasms, especially in adult T-cell leukemias and acute leukemias. Int J Hematol 2004, 80:52-58.
• [21]Yang M, Liu Y, Lu S, Wang Z, Wang R, Zi Y, Li J: Analysis of the expression levels of survivin and VEGF in patients with acute lymphoblastic leukemia. Exp Ther Med 2013, 5:305-307.
• [22]El-Attar HA, Kandil MH, El-Kerm YM, El-Ghandour MK: Comparison of serum survivin and alpha fetoprotein in Egyptian patients with hepatocellular carcinoma associated with hepatitis C viral infection. Asian Pac J Cancer Prev 2010, 11:897-903.
• [23]Bokarewa M, Lindblad S, Bokarew D, Tarkowski A: Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis. Arthritis Res Ther 2005, 7:R349-R358. BioMed Central Full Text
• [24]ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med 2005, 171:912-930.
• [25]Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB: Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 2004, 113:59-65.
• [26]Faul F, Erdfelder E, Buchner A, Lang AG: Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009, 41:1149-1160.
• [27]Khan S, Aspe JR, Asumen MG, Almaguel F, Odumosu O, Acevedo-Martinez S, De Leon M, Langridge WH, Wall NR: Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential. Br J Cancer 2009, 100:1073-1086.
• [28]Toldi G, Molvarec A, Stenczer B, Muller V, Eszes N, Bohacs A, Bikov A, Rigo J Jr, Vasarhelyi B, Losonczy G, Tamasi L: Peripheral T(h)1/T(h)2/T(h)17/regulatory T-cell balance in asthmatic pregnancy. Int Immunol 2011, 23:669-677.
• [29]Molvarec A, Szarka A, Walentin S, Beko G, Karadi I, Prohaszka Z, Rigo J Jr: Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia. Reprod Biol Endocrinol 2011, 9:124. BioMed Central Full Text
• [30]Bikov A, Bohacs A, Eszes N, Weiszhar Z, Ivancso I, Muller V, Rigo J Jr, Losonczy G, Tamasi L, Horvath I: Circulating and exhaled vascular endothelial growth factor in asthmatic pregnancy. Biomarkers 2012, 17:648-654.
• [31]Beierle EA, Nagaram A, Dai W, Iyengar M, Chen MK: VEGF-mediated survivin expression in neuroblastoma cells. J Surg Res 2005, 127:21-28.
• [32]Formby B, Wiley TS: Bcl-2, survivin and variant CD44 v7-v10 are downregulated and p53 is upregulated in breast cancer cells by progesterone: inhibition of cell growth and induction of apoptosis. Mol Cell Biochem 1999, 202:53-61.
• [33]Tamasi L, Bohacs A, Pallinger E, Falus A, Rigo J Jr, Muller V, Komlosi Z, Magyar P, Losonczy G: Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics. Clin Exp Allergy 2005, 35:1197-1203.
• [34]Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR: Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2000, 2:469-475.
• [35]Molvarec A, Tamasi L, Losonczy G, Madach K, Prohaszka Z, Rigo J Jr: Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies. Cell Stress Chaperones 2010, 15:237-247.