Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012

Virology Journal

Ming Wang¹  Zhicong Yang¹  Zhijun Bai¹  Lei Luo¹  Jinmei Geng¹  Dahu Wang¹  Peng He¹  Peng Ding¹  Chun Chen¹  Xiaoquan Li¹  Huaping Xie¹  Ying Zhang¹  Biao Di¹ 

[1] Guangzhou Center for Disease Control and Prevention, NO.1, Qide Road, Baiyun District, Guangzhou, Guangdong, 510440, China

关键词: Molecular analysis;    Epidemiologic feature;    Coxsackievirus A6;    Foot and mouth disease;    Hand;   

Others  :  1148522
DOI  :  10.1186/1743-422X-11-157

 received in 2014-03-19, accepted in 2014-08-08,  发布年份 2014

【 摘 要 】

Background

Hand, foot and mouth disease (HFMD) is usually caused by Enterovirus 71(EV71), and Coxsackievirus A16 (CV-A16) in Guangzhou, the biggest city of South China. However, Coxsackievirus A6 (CV-A6) were observed increased dramatically from 2010–2012.

Methods

In order to understand and to describe the epidemiologic and genetic characteristics of CV-A6, specimens of 5482 suspected HFMD cases were collected and examined by real-time fluorescence PCR. All samples positive for enteroviruses were analyzed by descriptive statistics. Phylogenetic analysis of CV-A6 based on the VP1 sequences was performed to investigate molecular and evolutionary characteristics.

Results

Coxsackievirus A6 increased dramatically from 9.04% in 2010 to 23.21% in 2012 and became one of the main causative agents of HFMD in Guangzhou. CV-A6 attack rates were highest in one to two year olds (33.14%). Typical clinic symptoms of CV-A6 HFMD include fever (589/720, 81.81%), maculopopular rash and vesicular exanthema around the perioral area (408/720, 56.66%), intraoral (545/720, 75.69%), the buttock (395/720, 54.86%), the trunk (244/720, 33.89%), the knee (188/720, 26.11%), and the dorsal aspects of hands (437/720, 60.69%). Phylogenetic analysis showed the CV-A6 isolates in this study belonged to Cluster A1 and were similar to those found in Shanghai in 2011 and 2012 (JX495148, KC414735), Shenzhen in 2011 (JX473394), Japan in 2011 (AB649243, AB649246), France in 2010(HE572928), Thailand in 2012(JX556564) and Israel in 2012 and 2013(.KF991010, KF991012).

【 授权许可】

   
2014 Di et al.; licensee BioMed Central Ltd.

【 图 表 】

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