Toxicity after radiochemotherapy for glioblastoma using temozolomide - a retrospective evaluation

Radiation Oncology

Christian Rübe²  Ralf Ketter¹  Norbert Licht²  Jochen Fleckenstein²  Christian Berdel²  Marcus Niewald² 

[1] Department of Neurosurgery, Saarland University Hospital, Kirrberger Straße, D-66421 Homburg, Germany;Department of Radiotherapy and Radiation Oncology, Saarland University Hospital, Kirrberger Straße, D-66421 Homburg, Germany

关键词: Bone marrow;    Toxicity;    Chemotherapy;    Radiotherapy;    Glioblastoma;   

Others  :  1223874
DOI  :  10.1186/1748-717X-6-141

 received in 2011-07-26, accepted in 2011-10-21,  发布年份 2011

【 摘 要 】

Purpose

Retrospective evaluation of toxicity and results after radiochemotherapy for glioblastoma.

Methods

46 patients with histopathologically proven glioblastoma received simultaneous radiochemotherapy (RCT). The mean age at the beginning of therapy was 59 years, the mean Karnofsky performance index 80%. 44 patients had been operated on before radiotherapy, two had not. A total dose of 60 Gy was applied in daily single fractions of 2.0 Gy within six weeks, 75 mg/m²/day Temozolomide were given orally during the whole radiotherapy period.

Results

A local progression could be diagnosed in 34/46 patients (70%). The median survival time amounted to 13.6 months resulting in one-year and two-year survival probabilities of 48% and 8%, respectively.

Radiotherapy could be applied completely in 89% of the patients. Chemotherapy could be completed according to schedule only in 56.5%, the main reason being blood toxicity (50% of the interruptions). Most of those patients suffered from leucopenia and/or thrombopenia grade III and IV CTC (Common toxicity criteria). Further reasons were an unfavourable general health status or a rise of liver enzymes.

The mean duration of thrombopenia and leucopenia amounted to 64 and 20 days. In two patients, blood cell counts remained abnormal until death. In two patients we noticed a rise of liver enzymes. In one of these in the healing phase of hepatitis a rise of ASAT and ALAT CTC grade IV was diagnosed. These values normalized after termination of temozolomide medication. One patient died of pneumonia during therapy.

Conclusion

Our survival data were well within the range taken from the literature. However, we noticed a considerable frequency and intensity of side effects to bone marrow and liver. These lead to the recommendations that regular examinations of blood cell count and liver enzymes should be performed during therapy and temozolomide should not be applied or application should be terminated according to the criteria given by the manufacturer.

【 授权许可】

   
2011 Niewald et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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