Image-guided percutaneous renal cryoablation for stage 1 renal cell carcinoma with high surgical risk

World Journal of Surgical Oncology

Guo-Ping Shi¹  Yang Wang²  Hongqian Guo³  Weidong Gan³  Yang Yang³  Rong Yang³  Wang Wei³  Xiaoxiang Chen³  Mingxin Zhang³  Xiang Yan³ 

[1] Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA;Department of Radiology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China;Department of Urology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China

关键词: Local anesthesia;    Renal cell carcinoma;    Cryoablation;   

Others  :  1218716
DOI  :  10.1186/s12957-015-0610-x

 received in 2014-12-04, accepted in 2015-05-22,  发布年份 2015

【 摘 要 】

Background

This study was undertaken to evaluate the feasibility, safety, and therapeutic effects of percutaneous renal cryoablation under local anesthesia with conscious sedation for patients who have unresectable stage 1 (T1NoMo) renal cell carcinoma (RCC) in high surgical risk.

Methods

Eighteen patients who were not candidates for surgery underwent primary cryosurgery guided by gray-scale ultrasound. Contrast-enhanced ultrasonography (CEUS) and contrast-enhanced computed tomography (CT) were performed to evaluate treatment at completion.

Results

The mean follow-up period was 26.8 months (range, 12–56 months). All tumors were biopsied before cryosurgery. Seventeen tumors remained free of enhancement during follow-up period. No major complications associated with cryoablation procedures were found though two instances of subcapsular hematomas, one of retroperitoneal errhysis and one of nausea, were seen after cryoablation. One patient had a local recurrence of tumor and received additional cryoablation. Local tumor control rate was 100 % of T1NoMo tumors including the recurrence case who underwent additional cryoablation.

Conclusions

Percutaneous cryoablation can be recommended as a feasible, safe, and promising therapy for the treatment of renal tumor, especially those unresectable stage 1 RCC, with a low risk of complications.

【 授权许可】

   
2015 Yan et al.

【 图 表 】

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