Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009

Virology Journal

Fu-Chun Zhang³  Cheng-Feng Qin¹  Jian Wang³  E-De Qin¹  Shun-Ya Zhu¹  Yong-Qiang Deng¹  Man Yu¹  Wei-Ze Zhou²  Wen-Xin Hong³  Xue-Dong Yu¹  Tao Jiang¹ 

[1] State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No.20 Dongda Street, Fengtai District, Beijing, 100071, China;The Third People’s Hospital of Huizhou, Huizhou, 516002, China;Guangzhou No.8 People’s Hospital, Guangzhou Medical College, Guangzhou, 510060, China

关键词: Co-circulation;    Genotype;    Family cluster;    Dengue virus type 3;   

Others  :  1154406
DOI  :  10.1186/1743-422X-9-125

 received in 2011-11-25, accepted in 2012-06-14,  发布年份 2012

【 摘 要 】

Dengue is emerging as the most important mosquito borne viral disease in the world. In mainland China, sporadic and large outbreaks of dengue illness caused by the four serotypes of dengue virus (DENV-1 to DENV-4) have been well documented. Guangdong province is the major affected area in China, and DENV-1 has dominantly circulated in Guangdong for a long time. In this study, a family cluster of DENV-3 infection in Guangzhou was described. Three cases were diagnosed as dengue fever based on clinical manifestation, serological and RT-PCR assays. Two DENV-3 strains were isolated in C6/36 cells and the complete genome sequences were determined. Phylogenetic analysis revealed that the new DENV-3 isolates from the family cluster were grouped within genotype III. Considering the fact that several DENV-3 strains within genotype V were also identified in Guangzhou in 2009, at least two genotypes of DENV-3 co-circulated in Guangzhou. Careful investigation and virological analysis should be warranted in the future.

【 授权许可】

   
2012 Jiang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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