From stillness to motion: 80 years after the first description of Taenia solium oncosphere hatching

Particle and Fibre Toxicology

Ana Flisser³  Pablo Maravilla²  Fernando González-Domínguez²  Joaquin Carrillo-Farga⁴  Adriana Garza-Rodríguez²  Fela Mendlovic¹ 

[1]Facultad de Ciencias de la Salud, Universidad Anáhuac del Norte, México Norte, Av. Universidad Anáhuac 46, Huixquilucan Estado de México 52786, Mexico

[2]Dirección de Investigación, Hospital General “Dr. Manuel Gea González” SSA, México 14000 DF, Mexico

[3]Facultad de Medicina, Universidad Nacional Autónoma de México, México 04510 DF, Mexico

[4]Instituto de Hematopatología, Tamaulipas 131, Col. Cuajimalpa, México 05000 DF, Mexico

关键词: Video;    Taenia solium;    Pigs;    Oncospheres;    Neurocysticercosis;    Humans;    Hatching;    Cysticercosis;    Activation;   

Others  :  822996
DOI  :  10.1186/1756-3305-7-12

 received in 2013-11-25, accepted in 2013-11-27,  发布年份 2014

【 摘 要 】

Background

Human neurocysticercosis (NCC) is a considered public health problem in many underdeveloped and developing countries. Because of the enormous increase in international tourism and migration, NCC nowadays is also found in some developed countries. Our group was the first to demonstrate that tapeworm carriers in the household are the main risk factor for acquiring cysticercosis in humans and pigs, since the disease results from the ingestion of microscopic tapeworm eggs.

Findings

We had the opportunity to film the liberation of the embryo from the oncospheral membrane after the hatching of the egg, which is the activation process required for intestinal wall invasion by the onchosphere. Yoshino (J Formosa Med Ass 32:139-142, 1933) described with great detail in diagrams and photographs this process eighty years ago after he infected himself with three living cysticerci in order to study the life cycle of Taenia solium. Other authors further described this process. Nevertheless it has never been filmed before. The purpose of this paper is to shift from stillness to motion since we can now show for the first time a movie of an activated oncosphere and its release from the oncospheral membrane.

Conclusion

Oncospheral activation is the requisite for T. solium embryos to invade the intestinal mucosa and develop into cysticerci. This process has been amply described but here it is shown for the first time in motion; thus it may be of interest for readers of the journal and useful for educational purposes towards the control of NCC.

【 授权许可】

   
2014 Mendlovic et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 1.

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