Is the in vivo dosimetry with the OneDosePlusTM system able to detect intra-fraction motion? A retrospective analysis of in vivo data from breast and prostate patients

Radiation Oncology

Riccardo Santoni²  Luana Di Murro²  Rosaria Barbarino²  Grazia Tortorelli²  Barbara Tolu²  Elisabetta Ponti²  Mauro Rebuzzi²  Alessia Lo Bosco¹  Marco D’Andrea³  Maria Daniela Falco² 

[1] Department of Physics, Tor Vergata University, V. della Ricerca Scientifica 1, 00133, Rome, Italy;Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, Tor Vergata University General Hospital, V.le Oxford 81, 00133, Rome, Italy;Laboratory of Medical Physics and Expert Systems, National Cancer Institute Regina Elena, V. E. Chianesi 53, 00144, Rome, Italy

关键词: Intra-fraction motion error;    In vivo dosimetry;    MOSFET detector;    OneDosePlus^TM system;   

Others  :  1160819
DOI  :  10.1186/1748-717X-7-97

 received in 2012-03-08, accepted in 2012-06-05,  发布年份 2012

【 摘 要 】

Background

The OneDosePlus^TM system, based on MOSFET solid-state radiation detectors and a handheld dosimetry reader, has been used to evaluate intra-fraction movements of patients with breast and prostate cancer.

Methods

An Action Threshold (AT), defined as the maximum acceptable discrepancy between measured dose and dose calculated with the Treatment Planning System (TPS) (for each field) has been determined from phantom data. To investigate the sensitivity of the system to direction of the patient movements, fixed displacements have been simulated in phantom. The AT has been used as an indicator to establish if patients move during a treatment session, after having verified the set-up with 2D and/or 3D images. Phantom tests have been performed matching different linear accelerators and two TPSs (TPS1 and TPS2).

Results

The ATs have been found to be very similar (5.0% for TPS1 and 4.5% for TPS2). From statistical data analysis, the system has been found not sensitive enough to reveal displacements smaller than 1 cm (within two standard deviations). The ATs applied to in vivo treatments showed that among the twenty five patients treated for breast cancer, only four of them moved during each measurement session. Splitting data into medial and lateral field, two patients have been found to move during all these sessions; the others, instead, moved only in the second part of the treatment. Patients with prostate cancer have behaved better than patients with breast cancer. Only two out of twenty five moved in each measurement session.

Conclusions

The method described in the paper, easily implemented in the clinical practice, combines all the advantages of in vivo procedures using the OneDosePlus^TM system with the possibility of detecting intra-fraction patient movements.

【 授权许可】

   
2012 Falco et al.; licensee BioMed Central Ltd.

【 图 表 】

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