Schistosomiasis in Malawi: a systematic review

Particle and Fibre Toxicology

Paul Bloch²  Samuel Jemu⁵  Sekeleghe Kayuni³  Adamson S Muula⁴  John R Sadalaki⁴  Peter Makaula¹ 

[1] Research for Health Environment and Development, Mangochi, Malawi;Steno Health Promotion Center, Steno Diabetes Center, Niels Steensens Vej 8, Gentofte, DK-2820, Denmark;Medical Aid Society of Malawi (MASM) Medi Clinics, Blantyre, Malawi;School of Public Health and Family Medicine, Department of Public Health, College of Medicine, University of Malawi, Chichiri, Blantyre 3, Malawi;Ministry of Health, Capital City, Lilongwe 3, Malawi

关键词: Malawi;    Schistosoma mansoni;    Schistosoma haematobium;    Schistosomiasis;    Bulinus;    Biomphalaria;    Bilharzia;   

Others  :  1148670
DOI  :  10.1186/s13071-014-0570-y

 received in 2014-08-15, accepted in 2014-11-25,  发布年份 2014

【 摘 要 】

Introduction

Schistosomiasis remains an important public health problem that undermines social and economic development in tropical regions of the world, mainly Sub-Saharan Africa. We are not aware of any systematic review of the literature of the epidemiology and transmission of schistosomiasis in Malawi since 1985. Therefore, we reviewed the current state of knowledge of schistosomiasis epidemiology and transmission in this country and identified knowledge gaps and relevant areas for future research and research governance.

Methods

We conducted computer-aided literature searches of Medline, SCOPUS and Google Scholar using the keywords: “schistosomiasis”, “Bilharzia”, “Bulinus” and “Biomphalaria” in combination with “Malawi”. These searches were supplemented by iterative reviews of reference lists for relevant publications in peer reviewed international scientific journals or other media. The recovered documents were reviewed for their year of publication, location of field or laboratory work, authorship characteristics, ethics review, funding sources as well as their findings regarding parasite and intermediate host species, environmental aspects, geographical distribution, seasonality of transmission, and infection prevalence and intensities.

Review

A total of 89 documents satisfied the inclusion criteria and were reviewed. Of these, 76 were published in international scientific journals, 68 were peer reviewed and 54 were original research studies. Most of the documents addressed urinary schistosomiasis and about two thirds of them dealt with the definitive host. Few documents addressed the parasites and the intermediate hosts. While urinary schistosomiasis occurs in most parts of Malawi, intestinal schistosomiasis mainly occurs in the central and southern highlands, Likoma Island and Lower Shire. Studies in selected communities estimated prevalence rates of up to 94.9% for Schistosoma haematobium and up to 67.0% for Schistosoma mansoni with considerable geographical variation. The main intermediate host species are Bulinus globosus and Bulinus nyassanus for urinary schistosomiasis and Biomphalaria pfeifferi for intestinal schistosomiasis. Seasonality of transmission tends to vary according to geographical, environmental, biological and behavioural factors.

Conclusion

Transmission of schistosomiasis in Malawi appears to be highly focal, with considerable variation in space and time. Many locations have not been covered by epidemiological investigations and, thus, information on the transmission of schistosomiasis in Malawi remains fragmented. Functional infection risk assessment systems based on systematic investigations and surveillance are required for developing informed prevention and control strategies.

【 授权许可】

   
2014 Makaula et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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