Epidemiology of dyslipidemia in Chinese adults: meta-analysis of prevalence, awareness, treatment, and control

Population Health Metrics

Seng Chuen Tan³  Xiaoping Xie¹  Lin Gao²  Yuanxiu Huang² 

[1]Outcomes Research, Pfizer Investment Co. Ltd, Beijing, China

[2]School of Public Health, Central South University, Changsha, China

[3]Health Economics & Outcomes Research, IMS Health Asia Pacific, 8 Cross Street, #21-01/02/03 PWC Building, Singapore 048424, Singapore

关键词: Meta-analysis;    Control rate;    Treatment rate;    Awareness rate;    Prevalence;    Dyslipidemia;   

Others  :  1132058
DOI  :  10.1186/s12963-014-0028-7

 received in 2014-03-12, accepted in 2014-10-01,  发布年份 2014

【 摘 要 】

Background

Numerous epidemiology studies on dyslipidemia have been conducted in China. However, a nationally representative estimate for dyslipidemia prevalence is lacking. The aim of this study is to appraise the nationwide prevalence, awareness, treatment, and control rates of dyslipidemia in adults in China.

Methods

We performed a systematic review of the related observational studies published since 2003 by searching English and Chinese literature databases. Meta-analyses were conducted in eligible studies using a random effect model to summarize the dyslipidemia prevalence, awareness, treatment, and control rates. Heterogeneity and publication bias were analyzed. Sensitivity analyses were performed to explain heterogeneity and examine the impact of study quality on the results of meta-analyses.

Results

Thirty-eight papers were included for meta-analyses, with a total sample size of 387,825. The prevalence, awareness, treatment, and control rates of dyslipidemia were 41.9% (95% CI: 37.7% – 46.2%), 24.4% (95% CI: 14.4% – 38.4%), 8.8% (95% CI: 7.7% – 10.0%), and 4.3% (95% CI: 4.1% – 4.5%), respectively. The prevalence of hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia, low levels of high-density lipoprotein cholesterol, and high levels of low-density lipoprotein cholesterol were 10.1% (95% CI: 5.8% – 16.9%), 17.7% (95% CI: 14.0% – 22.1%), 5.1% (95% CI: 3.1% – 8.2%), 11.0% (95% CI: 8.0% – 15.0%), and 8.8% (95% CI: 4.1% – 17.8%), respectively. Sensitivity analyses revealed that males had a higher prevalence of dyslipidemia (43.2%) than females (35.6%). Study samples of age 30 and above in the eastern region tended to have higher prevalence of dyslipidemia. The quality of the studies has a slight impact on the pooled estimates.

Conclusions

The overall pooled prevalence of dyslipidemia in Chinese adults was estimated to be 41.9%, with males having a higher rate than females.

【 授权许可】

   
2014 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Pisciotta L, Bertolini S, Pende A: Lipoproteins, stroke and statins.Curr Vasc Pharmacol 2013, [Epub ahead of print].
• [2]Chinese guidelines on prevention and treatment of dyslipidemia in adults Zhonghua Xin Xue Guan Bing Za Zhi 2007, 35(5):390-419.
• [3]Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB: Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000, 283(15):2008-2012.
• [4]Prins J, Blanker MH, Bohnen AM, Thomas S, Bosch JL: Prevalence of erectile dysfunction: a systematic review of population-based studies. Int J Impot Res 2002, 14(6):422-432.
• [5]Schmidt FL, Oh IS, Hayes TL: Fixed- versus random-effects models in meta-analysis: model properties and an empirical comparison of differences in results. Br J Math Stat Psychol 2009, 62(Pt 1):97-128.
• [6]Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J: Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods 2006, 11(2):193-206.
• [7]Higgins JP, Thompson SG, Deeks JJ, Altman DG: Measuring inconsistency in meta-analyses. BMJ 2003, 327(7414):557-560.
• [8]Chen YY, Zhu LP, Li A: Epidemiologic characteristics of dyslipidemia in Jiangxi province adults. Pract Prev Med 2013, 20:234-236.
• [9]Fu YY, Yu JM, Wang JH: Awareness factors analysis of abonormal blood lipid in Beijing communities. Chin J Pract Intern Med 2010, 1:38-40.
• [10]Fu YY, Yu JM, Wang JH: Current status of dyslipidemia among overweight and obese population in Beijing community. Chin J Cardiol 2010, 28:562-566.
• [11]Gao B, Chen F, Zhang YP: Cross-sectional survey of lipid level in adults orth of nof Qinlin in Shanxi. Chin J Arterioscler 2010, 10:824-827.
• [12]Gao Y, Liu YB, Li ZM: Relationships between lipid level and fat distribution in Jilin rural area middle-aged population. Chin J Gerontol 2013, 33:2107-2109.
• [13]Guan ZJ, Xia CY: The study of prevention and treatment on the incidence of dyslipidemia of rural population in medical examination in Beijing. Chin Foreign Med Res 2012, 10:63-65.
• [14]Guo MH, Han XY, Li Z: The survey about prevalent charateristics of common chronic diseases among adults in Beijing Chaoyang district. Chin J Prev Control Chronic Dis 2013, 21:294-296.
• [15]Hu XL, Xie HB, Xu WH: Dyslipidemia and associated risk factors among residents in the Baimashan Ecological Area of Suichang. Prev Treat Cardi -Cereb Vasc Dis 2012, 12:201-203.
• [16]Hu XZ, Wang ST, Liu ZS: Correlation of dyslipidemia distribution and chronic kidney disease in Zhengzhou older population. Chin J Gerontol 2011, 31:3584-3586.
• [17]Jin LZ, Huang RH, Wu WM: Investigation on status of lipid disorders and chronic noninfectious diseases aggregation in Doumen Rural area of Zhuhai city. J Sun Yat Sen Univ (Med Sci) 2009, 30:151-154.
• [18]Li J: Hypertension on Middle-Elderly City Community Residents in Taishan District of Tai’an City. Taishan Medical University, Tai’an, China; 2010.
• [19]Li J, Zhang YJ, Sun YH: Investigation of chronic disease incidence in Beijing Sunhe area residents. Chin J Gen Pract 2011, 9:600-601.
• [20]Li JH, Wang LM, Li YC, Bi YF, Jiang Y, Mi SQ, Dai M, Xu Y, Ning G, Zhao WH: Epidemiologic characteristics of dyslipidemia in Chinese adults 2010. Zhonghua Yu Fang Yi Xue Za Zhi 2012, 46(5):414-418.
• [21]Li JH, Wang LM, Mi SQ, Zhang M, Li YC, Jiang Y, Xu Y, Dai M, Wang LH: Awareness rate, treatment rate and control rate of dyslipidemia in Chinese adults, 2010. Zhonghua Yu Fang Yi Xue Za Zhi 2012, 46(8):687-691.
• [22]Li SL, Yu JX, Zhang YL: Epidemiology of dyslipidemia in residents of Yan’an district. S China J Prev Med 2011, 37:17-20.
• [23]Li XH, Li L, Qiao Y: Epidemiologic analysis of dyslipidemia in adult Tibetan population in Tibet. Chin Circ J 2009, 24:458-460.
• [24]Li Y, Li WS, Qu WH: Investigation of prevalence rate of dyslipidemia among immigrant population of rural residents in three gorges reservoir area. Chin Med Herald 2012, 9:108-112.
• [25]Li Y, Zhai L, Wang HB: The status quo of common chronic diseases among adults in Beijing Haidian district. Chin J Prev Control Chronic Dis 2010, 18:261-264.
• [26]Liang YQ, Zhou YY, Wu YQ: Epidemiologic survey of dyslipidemia among residents aged ≥ 60 years in Rong-Gui community and relationship between dyslipidemia and inter-arm blood pressure difference. New Med 2013, 2:97-100.
• [27]Liao XY, Xu GF, Wu J: Epidemiological study of hyperlipidemia with cardiovascular risk factors in urban and rural communities. West China Med J 2013, 1:14-17.
• [28]Liu DW, Wan J, Liu ZS, Wang P, Cheng GY, Shi XZ: Association between dyslipidemia and chronic kidney disease: a cross-sectional study in the middle-aged and elderly Chinese population. Chin Med J (Engl) 2013, 126(7):1207-1212.
• [29]Liu XY, Liu L, Zhao Y: Investigation of dyslipidemia prevalence and risk factors in Yinchuan city adults. J Ningxia Med Univ 2011, 33:27-31.
• [30]Luo R, Wang YH, Wang XL: Distribution of dyslipidemia among adult residents in Chongqing. J Chongqing Med Univ 2010, 25(7):1086-1088.
• [31]Luo WP, Liu LX, Ma JP: The analysis about residents chronic disease and risk factors of behavior in Xinjiang monitoring stations in 2010. Bull Dis Control Prev (China) 2013, 28:20-23.
• [32]Mo JF, Song XL, Xu YJ: The correlation research of dyslipidemia prevalence and risk factors about in Guangdong province adults. S China J Prev Med 2013, 39:11-17.
• [33]Pang QY, Han B, You A: The Effect Evaluation and Research about Body Mass Index, Waist Circumference and Girth Ratio Predict Dyslipidemia. 1st Jinjiluyu Epidemilogy Symposium, Changzhi, China; 2008.
• [34]Pang QY, Yu DH, Lu J: Distribution characteristics of dyslipedemia and related-risk factors in Henan rural residents. J Zhengzhou Univ (Med Sci) 2009, 44:547-550.
• [35]Shao YQ: Epidemiological study on lipid level and its abnormal rate of Wenzhou community population. Mod Pract Med 2011, 23:22-25.
• [36]Sheng L, Ye P, Xu RY: Dyslipidemia distribution characteristics of Beijing older male residents. Clin Focus 2011, 26:1572-1574.
• [37]Wang CJ, Li YQ, Li LL, Wang L, Zhao JZ, You AG, Guo YR, Li WJ: Relationship between resting pulse rate and lipid metabolic dysfunctions in Chinese adults living in rural areas. PLoS One 2012, 7(11):e49347.
• [38]Wang JH, Hu DY, Fu YY: Prevalence of dyslipidemia and borderline dyslipidemia and other risk factors of coronary heart disease in residents from Beijing communities. Chin J Cardilol 2010, 38:175-180.
• [39]Wu ZF, Wang L, Ma GQ: Relationship between body mass index and blood lipid or blood pressure in Tianjin suburbs senile male cohort. Chin J Prev Control Chronic Non Commun Dis 2009, 17:293-294.
• [40]Yin L, Li GC, Liu LY: Intervention of main chronic disease and related factors in Hunan province community residents. Pract Prev Med 2011, 18(6):1148-1150.
• [41]You A: The Prevalence and Influencing Factors of Type 2 Diabetes Mellitus in a Rural Population of Henan Province. Zhengzhou University, Zhengzhou, China; 2009.
• [42]Yuan XH: Investigation of the prevalence of hyperlipidaemia in Yunfu city. China Mod Med 2012, 9:176-177.
• [43]Zhang XW, Ye Z, Zhou D, Zhang J, Wang H, He QF, Fang L, Zhao M, Shu D, Hu R, Gong W: Prevalence of dyslipidemia and its distribution among adults, a cross-sectional study in Zhejiang. Dis Surveill 2012, 27(5):395-399.
• [44]Zhao YZ, Feng SG, Li GM: The epidemiological study on dyslipidemia in Nanchong community. Med J West China 2012, 24:1948-1950.
• [45]Zhou WJ, Zhu Y, Liu P: Epidemiology survey of dyslipidemia among residents in Wuxi City and its influence factors. Jiangsu J Prev Med 2012, 23:20-22.
• [46]Zhao WH, Zhang J, You Y, Man QQ, Li H, Wang CR, Zhai Y, Li Y, Jin SG, Yang XG: Epidemiologic characteristics of dyslipidemia in people aged 18 years and over in China. Zhonghua Yu Fang Yi Xue Za Zhi 2005, 39(5):306-310.
• [47]Toth PP, Potter D, Ming EE: Prevalence of lipid abnormalities in the United States: the National Health and Nutrition Examination Survey 2003–2006. J Clin Lipidol 2012, 6(4):325-330.
• [48]Zhou B, Rao X, Dennis BH, Li Y, Zhuo Q, Folsom AR, Yang J, Li Y, Stamler J, Cao T, Guo C, Thomas RP, Zhao L, Liu X, Tian X, Zheng R: The relationship between dietary factors and serum lipids in Chinese urban and rural populations of Beijing and Guangzhou. PRC-USA Cardiovascular and Cardiopulmonary Research Group. Int J Epidemiol 1995, 24(3):528-534.
• [49]Chen CM: Overview of obesity in Mainland China. Obes Rev 2008, 9(Suppl 1):14-21.
• [50]Goff DC Jr, Bertoni AG, Kramer H, Bonds D, Blumenthal RS, Tsai MY, Psaty BM: Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation 2006, 113(5):647-656.
• [51]Taylor HA Jr, Akylbekova EL, Garrison RJ, Sarpong D, Joe J, Walker E, Wyatt SB, Steffes MW: Dyslipidemia and the treatment of lipid disorders in African Americans. Am J Med 2009, 122(5):454-463.
• [52]Thorlund K, Imberger G, Johnston BC, Walsh M, Awad T, Thabane L, Gluud C, Devereaux PJ, Wetterslev J: Evolution of heterogeneity (I2) estimates and their 95% confidence intervals in large meta-analyses. PLoS One 2012, 7:e39471.